FLT1
Summary: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fms related tyrosine kinase 1 | MIM:165070 | Ensembl:ENSG00000102755 | HGNC:HGNC:3763 | PA28180 | 13q12.3 |
GO terms in FLT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | TAS | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| MF | IMP | GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IDA | GO:0036326 | VEGF-A-activated receptor activity |
| MF | IDA | GO:0036327 | VEGF-B-activated receptor activity |
| MF | IDA | GO:0036332 | placental growth factor-activated receptor activity |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IDA | GO:0002548 | monocyte chemotaxis |
| BP | TAS | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IMP | GO:0010863 | positive regulation of phospholipase C activity |
| BP | IMP | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IMP | GO:0016477 | cell migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IDA | GO:0036323 | vascular endothelial growth factor receptor-1 signaling pathway |
| BP | IEA | GO:0038084 | vascular endothelial growth factor signaling pathway |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0048514 | blood vessel morphogenesis |
| BP | ISS | GO:0048598 | embryonic morphogenesis |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IGI | GO:1905563 | negative regulation of vascular endothelial cell proliferation |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005768 | endosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
Gene expression in normal tissue: FLT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FLT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR |
| reactome | R-HSA-194313 | VEGF ligand-receptor interactions |
| reactome | R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| pharmgkb | PA165959425 | Pathway_PA165959425 |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | glypican_1pathway | Glypican 1 network |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | vegf_vegfr_pathway | VEGF and VEGFR signaling network |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| smpdb | SMP00420 | Bevacizumab Action Pathway |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD241 | Sunitinib | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FLT1
CLASSFICATION
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