Summary: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009].

fms related tyrosine kinase 1MIM:165070Ensembl:ENSG00000102755HGNC:HGNC:3763PA2818013q12.3

GO terms in FLT1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFTASGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIDAGO:0005021vascular endothelial growth factor-activated receptor activity
MFIMPGO:0005021vascular endothelial growth factor-activated receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019838growth factor binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIDAGO:0036326VEGF-A-activated receptor activity
MFIDAGO:0036327VEGF-B-activated receptor activity
MFIDAGO:0036332placental growth factor-activated receptor activity
BPIDAGO:0002548monocyte chemotaxis
BPTASGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007275multicellular organism development
BPTASGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIMPGO:0010863positive regulation of phospholipase C activity
BPIMPGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIMPGO:0016477cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIEAGO:0030154cell differentiation
BPIDAGO:0030335positive regulation of cell migration
BPIDAGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPIBAGO:0033674positive regulation of kinase activity
BPIDAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIDAGO:0036323vascular endothelial growth factor receptor-1 signaling pathway
BPIEAGO:0038084vascular endothelial growth factor signaling pathway
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIDAGO:0043410positive regulation of MAPK cascade
BPIMPGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPIMPGO:0045766positive regulation of angiogenesis
BPIDAGO:0046777protein autophosphorylation
BPIDAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPISSGO:0048514blood vessel morphogenesis
BPISSGO:0048598embryonic morphogenesis
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIGIGO:1905563negative regulation of vascular endothelial cell proliferation
CCTASGO:0005615extracellular space
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0015629actin cytoskeleton
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex

Gene expression in normal tissue: FLT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLT1

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194306Neurophilin interactions with VEGF and VEGFR
reactomeR-HSA-194313VEGF ligand-receptor interactions
reactomeR-HSA-195399VEGF binds to VEGFR leading to receptor dimerization
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartano1pathwayactions of nitric oxide in the heart
biocartavegfpathwayvegf hypoxia and angiogenesis
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway
pidglypican_1pathwayGlypican 1 network
pidhif2pathwayHIF-2-alpha transcription factor network
pids1p_s1p3_pathwayS1P3 pathway
pidvegf_vegfr_pathwayVEGF and VEGFR signaling network
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
smpdbSMP00420Bevacizumab Action Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328393
iGMDRD512nutlin 34
iGMDRD446LY 21832403
iGMDRD85Ursolic acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLT1