MAP3K12


Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].

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GO terms in MAP3K12


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005737 cytoplasm
CC ISS GO:0005829 cytosol
CC ISS GO:0005886 plasma membrane
CC ISS GO:0016020 membrane
CC IEA GO:0030426 growth cone
BP IBA GO:0000165 MAPK cascade
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Gene expression in normal tissue: MAP3K12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K12


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Database
Pathway ID
Pathway Des.
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP422 MAPK Cascade
wikipathways WP481 Insulin Signaling
pid p38alphabetapathway Regulation of p38-alpha and p38-beta
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD705 Nakiterpiosin 3
iGMDRD289 Parthenolide 1
iGMDRD318 PAC-1 2
iGMDRD137 Indisulam 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K12

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Cancer
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No matching records found

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