MAP3K12
Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 12 | MIM:600447 | Ensembl:ENSG00000139625 | HGNC:HGNC:6851 | PA30595 | 12q13.13 |
GO terms in MAP3K12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016020 | membrane |
| CC | IEA | GO:0030426 | growth cone |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007254 | JNK cascade |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | ISS | GO:0016572 | histone phosphorylation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:2000672 | negative regulation of motor neuron apoptotic process |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004706 | JUN kinase kinase kinase activity |
| MF | IEA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: MAP3K12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP481 | Insulin Signaling |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| biocarta | mapkpathway | mapkinase signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD698 | Neratinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K12
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