CDC73
Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 73 | MIM:607393 | Ensembl:ENSG00000134371 | HGNC:HGNC:16783 | PA29464 | 1q31.2 |
GO terms in CDC73
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000993 | RNA polymerase II core binding |
| MF | IDA | GO:0000993 | RNA polymerase II core binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0016593 | Cdc73/Paf1 complex |
| CC | IDA | GO:0016593 | Cdc73/Paf1 complex |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001558 | regulation of cell growth |
| BP | ISS | GO:0001711 | endodermal cell fate commitment |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | IMP | GO:0006378 | mRNA polyadenylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0010390 | histone monoubiquitination |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | ISS | GO:0019827 | stem cell population maintenance |
| BP | IDA | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IMP | GO:0031442 | positive regulation of mRNA 3'-end processing |
| BP | IMP | GO:0031648 | protein destabilization |
| BP | IBA | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter |
| BP | IDA | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter |
| BP | IDA | GO:0033523 | histone H2B ubiquitination |
| BP | IBA | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0045638 | negative regulation of myeloid cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | IMP | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | ISS | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IMP | GO:1902808 | positive regulation of cell cycle G1/S phase transition |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| BP | IDA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
Gene expression in normal tissue: CDC73
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC73
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
| wikipathways | WP2853 | Endoderm Differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD614 | Dabrafenib | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD660 | GSK-1070916 | 1 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC73
CLASSFICATION
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