EPHA1
Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor A1 | MIM:179610 | Ensembl:ENSG00000146904 | HGNC:HGNC:3385 | PA27817 | 7q34-q35 |
GO terms in EPHA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IDA | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IDA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | TAS | GO:0035019 | somatic stem cell population maintenance |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043087 | regulation of GTPase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | ISS | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0090630 | activation of GTPase activity |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IDA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
Gene expression in normal tissue: EPHA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
| pid | epha_fwdpathway | EPHA forward signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| wikipathways | WP3333 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHA1
CLASSFICATION
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