PEA15
Summary: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| proliferation and apoptosis adaptor protein 15 | MIM:603434 | Ensembl:ENSG00000162734 | HGNC:HGNC:8822 | PA33166 | 1q23.2 |
GO terms in PEA15
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0008643 | carbohydrate transport |
| BP | IEA | GO:0043278 | response to morphine |
| BP | IDA | GO:0046325 | negative regulation of glucose import |
| BP | IDA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | NAS | GO:0005875 | microtubule associated complex |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PEA15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PEA15
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| pid | p73pathway | p73 transcription factor network |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD209 | BRD6340 | 1 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD647 | StemRegenin 1 | 1 |
| iGMDRD557 | MGCD-265 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD862 | BRD-K94991378 | 1 |
| iGMDRD458 | GSK-319347A | 1 |
| iGMDRD370 | TPCA-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PEA15
CLASSFICATION
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