PEA15
Summary: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603434 Ensembl IDEnsembl:ENSG00000162734 HGNC IDHGNC:HGNC:8822 PHARMGKB IDPA33166 Map Location1q23.2 | |||||
GO terms in PEA15
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0008643 | carbohydrate transport |
| BP | IEA | GO:0043278 | response to morphine |
Gene expression in normal tissue: PEA15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PEA15
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PEA15
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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