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IRS2

Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinsulin receptor substrate 2 OMIM IDMIM:600797 Ensembl IDEnsembl:ENSG00000185950 HGNC IDHGNC:HGNC:6126 PHARMGKB IDPA375 Map Location13q34

Gene Categories:

KINASE CLINICALLY ACTIONABLE

GO terms in IRS2

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IEA	GO:0032991	protein-containing complex
BP	TAS	GO:0000165	MAPK cascade

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Gene expression in normal tissue: IRS2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IRS2

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-109704	PI3K Cascade
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-112412	SOS-mediated signalling
reactome	R-HSA-112412	SOS-mediated signalling
reactome	R-HSA-1257604	PIP3 activates AKT signaling

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD414	MST-312	3
iGMDRD506	Fedratinib	6
iGMDRD780	PP-30	1
iGMDRD152	179324-69-7	6

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRS2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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