IRS2
Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin receptor substrate 2 | MIM:600797 | Ensembl:ENSG00000185950 | HGNC:HGNC:6126 | PA375 | 13q34 |
GO terms in IRS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0032991 | protein-containing complex |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | ISS | GO:0002903 | negative regulation of B cell apoptotic process |
| BP | TAS | GO:0006006 | glucose metabolic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | NAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0009749 | response to glucose |
| BP | IMP | GO:0010748 | negative regulation of plasma membrane long-chain fatty acid transport |
| BP | IMP | GO:0010907 | positive regulation of glucose metabolic process |
| BP | IBA | GO:0019216 | regulation of lipid metabolic process |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0030879 | mammary gland development |
| BP | ISS | GO:0030890 | positive regulation of B cell proliferation |
| BP | IMP | GO:0032000 | positive regulation of fatty acid beta-oxidation |
| BP | ISS | GO:0032024 | positive regulation of insulin secretion |
| BP | IMP | GO:0032869 | cellular response to insulin stimulus |
| BP | ISS | GO:0033673 | negative regulation of kinase activity |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | TAS | GO:0038111 | interleukin-7-mediated signaling pathway |
| BP | IMP | GO:0045725 | positive regulation of glycogen biosynthetic process |
| BP | NAS | GO:0045725 | positive regulation of glycogen biosynthetic process |
| BP | IMP | GO:0046326 | positive regulation of glucose import |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:0055088 | lipid homeostasis |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019903 | protein phosphatase binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IEA | GO:0071889 | 14-3-3 protein binding |
Gene expression in normal tissue: IRS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112412 | SOS-mediated signalling |
| reactome | R-HSA-112412 | SOS-mediated signalling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74713 | IRS activation |
| reactome | R-HSA-74749 | Signal attenuation |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| pid | epopathway | EPO signaling pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pharmgkb | PA153627758 | Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_Leptin | Leptin |
| smpdb | SMP00391 | Insulin Signalling |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2879 | Farnesoid X Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD414 | MST-312 | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD77 | Itraconazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRS2
CLASSFICATION
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