MAPK8
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase 8 | MIM:601158 | Ensembl:ENSG00000107643 | HGNC:HGNC:6881 | PA283 | 10q11.22 |
GO terms in MAPK8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004705 | JUN kinase activity |
| MF | TAS | GO:0004705 | JUN kinase activity |
| MF | IBA | GO:0004707 | MAP kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IMP | GO:0035033 | histone deacetylase regulator activity |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007254 | JNK cascade |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IDA | GO:0007258 | JUN phosphorylation |
| BP | IDA | GO:0009411 | response to UV |
| BP | IBA | GO:0009612 | response to mechanical stimulus |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IMP | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IEA | GO:0031063 | regulation of histone deacetylation |
| BP | IMP | GO:0031281 | positive regulation of cyclase activity |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032880 | regulation of protein localization |
| BP | IDA | GO:0034198 | cellular response to amino acid starvation |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | IBA | GO:0048666 | neuron development |
| BP | IMP | GO:0051247 | positive regulation of protein metabolic process |
| BP | IDA | GO:0051403 | stress-activated MAPK cascade |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IMP | GO:0071276 | cellular response to cadmium ion |
| BP | IBA | GO:0071310 | cellular response to organic substance |
| BP | TAS | GO:0071345 | cellular response to cytokine stimulus |
| BP | IMP | GO:0090045 | positive regulation of deacetylase activity |
| BP | TAS | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IMP | GO:1902595 | regulation of DNA replication origin binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0030424 | axon |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0097441 | basal dendrite |
Gene expression in normal tissue: MAPK8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111446 | Activation of BIM and translocation to mitochondria |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-139910 | Activation of BMF and translocation to mitochondria |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-205043 | NRIF signals cell death from the nucleus |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-376172 | DSCAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-450341 | Activation of the AP-1 family of transcription factors |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| reactome | R-HSA-5693606 | DNA Double Strand Break Response |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9007892 | Interleukin-38 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | dsppathway | regulation of map kinase pathways through dual specificity phosphatases |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | il12pathway | il12 and stat4 dependent signaling pathway in th1 development |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | ranklpathway | bone remodeling |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
| netpath | Pathway_TWEAK | TWEAK |
| netpath | Pathway_Wnt | Wnt |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | endothelinpathway | Endothelins |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | epopathway | EPO signaling pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | foxopathway | FoxO family signaling |
| pid | glypican_3pathway | Glypican 3 network |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p53regulationpathway | p53 pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rapid_gr_pathway | Rapid glucocorticoid signaling |
| pid | reelinpathway | Reelin signaling pathway |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | trail_pathway | TRAIL signaling pathway |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| wikipathways | WP12 | Osteoclast Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP1584 | Type II diabetes mellitus |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP288 | NLR Proteins |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3874 | Canonical and Non-Canonical TGF-B signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4150 | Wnt Signaling in Kidney Disease |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD441 | TW 37 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK8
CLASSFICATION
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