Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].

mitogen-activated protein kinase 8MIM:601158Ensembl:ENSG00000107643HGNC:HGNC:6881PA28310q11.22

GO terms in MAPK8

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004705JUN kinase activity
MFTASGO:0004705JUN kinase activity
MFIBAGO:0004707MAP kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016301kinase activity
MFIPIGO:0019899enzyme binding
MFIMPGO:0035033histone deacetylase regulator activity
MFIPIGO:0042826histone deacetylase binding
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPIDAGO:0007254JNK cascade
BPTASGO:0007254JNK cascade
BPIDAGO:0007258JUN phosphorylation
BPIDAGO:0009411response to UV
BPIBAGO:0009612response to mechanical stimulus
BPIBAGO:0010468regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPTASGO:0016241regulation of macroautophagy
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIMPGO:0018107peptidyl-threonine phosphorylation
BPIEAGO:0031063regulation of histone deacetylation
BPIMPGO:0031281positive regulation of cyclase activity
BPIDAGO:0032091negative regulation of protein binding
BPIDAGO:0032880regulation of protein localization
BPIDAGO:0034198cellular response to amino acid starvation
BPIMPGO:0034614cellular response to reactive oxygen species
BPIBAGO:0035556intracellular signal transduction
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPISSGO:0042752regulation of circadian rhythm
BPIBAGO:0043065positive regulation of apoptotic process
BPTASGO:0043065positive regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIEAGO:0048511rhythmic process
BPIBAGO:0048666neuron development
BPIMPGO:0051247positive regulation of protein metabolic process
BPIDAGO:0051403stress-activated MAPK cascade
BPIDAGO:0071222cellular response to lipopolysaccharide
BPIEPGO:0071260cellular response to mechanical stimulus
BPIMPGO:0071276cellular response to cadmium ion
BPIBAGO:0071310cellular response to organic substance
BPTASGO:0071345cellular response to cytokine stimulus
BPIMPGO:0090045positive regulation of deacetylase activity
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIMPGO:1902595regulation of DNA replication origin binding
CCIBAGO:0043005neuron projection
CCISSGO:0097441basal dendrite

Gene expression in normal tissue: MAPK8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK8

DatabasePathway IDPathway Des.
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111446Activation of BIM and translocation to mitochondria
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-139910Activation of BMF and translocation to mitochondria
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-205043NRIF signals cell death from the nucleus
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-376172DSCAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-450341Activation of the AP-1 family of transcription factors
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9007892Interleukin-38 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
biocartaagrpathwayagrin in postsynaptic differentiation
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartaatmpathwayatm signaling pathway
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartaceramidepathwayceramide signaling pathway
biocartadsppathwayregulation of map kinase pathways through dual specificity phosphatases
biocartaegfpathwayegf signaling pathway
biocartafaspathwayfas signaling pathway (cd95)
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartaigf1pathwayigf-1 signaling pathway
biocartail12pathwayil12 and stat4 dependent signaling pathway in th1 development
biocartail1rpathwaysignal transduction through il1r
biocartaintegrinpathwayintegrin signaling pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartamapkpathwaymapkinase signaling pathway
biocartanfatpathwaynfat and hypertrophy of the heart
biocartangfpathwaynerve growth factor pathway (ngf)
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartapdgfpathwaypdgf signaling pathway
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartaranklpathwaybone remodeling
biocartastresspathwaytnf/stress related signaling
biocartatcrpathwayt cell receptor signaling pathway
biocartatollpathwaytoll-like receptor pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidar_tf_pathwayRegulation of Androgen receptor activity
pidatf2_pathwayATF-2 transcription factor network
pidavb3_opn_pathwayOsteopontin-mediated events
pidbcr_5pathwayBCR signaling pathway
pidcd40_pathwayCD40/CD40L signaling
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcdc42_pathwayCDC42 signaling events
pidceramide_pathwayCeramide signaling pathway
pidephrinbrevpathwayEphrin B reverse signaling
pidepopathwayEPO signaling pathway
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfaspathwayFAS (CD95) signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfoxopathwayFoxO family signaling
pidglypican_3pathwayGlypican 3 network
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil1pathwayIL1-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidncadherinpathwayN-cadherin signaling events
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp53regulationpathwayp53 pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrac1_pathwayRAC1 signaling pathway
pidrapid_gr_pathwayRapid glucocorticoid signaling
pidreelinpathwayReelin signaling pathway
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidrhoa_pathwayRhoA signaling pathway
pids1p_s1p2_pathwayS1P2 pathway
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidtcrjnkpathwayJNK signaling in the CD4+ TCR pathway
pidtrail_pathwayTRAIL signaling pathway
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
wikipathwaysWP12Osteoclast Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1584Type II diabetes mellitus
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2513Nanoparticle triggered regulated necrosis
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP288NLR Proteins
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP75Toll-like Receptor Signaling Pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD441TW 373
iGMDRD138PX 121
iGMDRD286Nsc 6328393

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK8