PRKX


Summary: This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase X-linkedMIM:300083Ensembl:ENSG00000183943HGNC:HGNC:9441PA33786Xp22.33

GO terms in PRKX


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004691cAMP-dependent protein kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
BPIMPGO:0001525angiogenesis
BPIMPGO:0001935endothelial cell proliferation
BPIMPGO:0007155cell adhesion
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0030099myeloid cell differentiation
BPIDAGO:0030155regulation of cell adhesion
BPIDAGO:0030334regulation of cell migration
BPIMPGO:0031589cell-substrate adhesion
BPIMPGO:0043542endothelial cell migration
BPIDAGO:0046777protein autophosphorylation
BPIDAGO:0060562epithelial tube morphogenesis
BPIDAGO:0060993kidney morphogenesis
BPIDAGO:2000696regulation of epithelial cell differentiation involved in kidney development
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm

Gene expression in normal tissue: PRKX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKX


DatabasePathway IDPathway Des.
wikipathwaysWP3929Chemokine signaling pathway
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD60Quinoclamine2
iGMDRD524ISX-92
iGMDRD268Cerulenin2
iGMDRD23Gossypol3
iGMDRD872BRD71372
iGMDRD871BRD63682
iGMDRD188Piperlongumine9
iGMDRD780PP-302
iGMDRD577BIX012943
iGMDRD782DC-45-A22
iGMDRD289Parthenolide1
iGMDRD52Rotenone3
iGMDRD870BRD636108
iGMDRD271Brefeldin A3
iGMDRD251ML1624
iGMDRD211(1S,3R)-RSL32
iGMDRD945ML2141
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD144NSC953978
iGMDRD546BMS-7548072
iGMDRD494Neopeltolide2
iGMDRD330BRD41323
iGMDRD248BRD43543

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKX

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