PRKX
Summary: This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase X-linked | MIM:300083 | Ensembl:ENSG00000183943 | HGNC:HGNC:9441 | PA33786 | Xp22.33 |
GO terms in PRKX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004691 | cAMP-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IMP | GO:0001525 | angiogenesis |
| BP | IMP | GO:0001935 | endothelial cell proliferation |
| BP | IMP | GO:0007155 | cell adhesion |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0030099 | myeloid cell differentiation |
| BP | IDA | GO:0030155 | regulation of cell adhesion |
| BP | IDA | GO:0030334 | regulation of cell migration |
| BP | IMP | GO:0031589 | cell-substrate adhesion |
| BP | IMP | GO:0043542 | endothelial cell migration |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0060562 | epithelial tube morphogenesis |
| BP | IDA | GO:0060993 | kidney morphogenesis |
| BP | IDA | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: PRKX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3929 | Chemokine signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD870 | BRD63610 | 8 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD144 | NSC95397 | 8 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD248 | BRD4354 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKX
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