WIF1

Summary: The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameWNT inhibitory factor 1
OMIM IDMIM:605186
Ensembl IDEnsembl:ENSG00000156076
HGNC IDHGNC:HGNC:18081
PHARMGKB IDPA38291
Map Location12q14.3

Gene Categories:

DRUGGABLE GENOME

GO terms in WIF1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005102 signaling receptor binding
MF IPI GO:0005515 protein binding
MF NAS GO:0017147 Wnt-protein binding
CC IBA GO:0005576 extracellular region
CC IEA GO:0005576 extracellular region
CC IBA GO:0009986 cell surface
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Gene expression in normal tissue: WIF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined4Longevity regulating pathway1ERK MAPK signaling1Biosynthesis of secondary metabolites1

Pathways in WIF1


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Database
Pathway ID
Pathway Des.
kegg hsa04310 Wnt signaling pathway - Homo sapiens (human)
pid ps1pathway Presenilin action in Notch and Wnt signaling
pid wnt_signaling_pathway Wnt signaling network
wikipathways WP3658 Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathways WP428 Wnt Signaling Pathway
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD61 Kinetin riboside 3
iGMDRD399 Selumetinib 3
iGMDRD885 Compound 110 4
iGMDRD23 Gossypol 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WIF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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