WIF1
Summary: The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WNT inhibitory factor 1 | MIM:605186 | Ensembl:ENSG00000156076 | HGNC:HGNC:18081 | PA38291 | 12q14.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in WIF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0017147 | Wnt-protein binding |
| CC | IBA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0009986 | cell surface |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IEA | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IBA | GO:0048856 | anatomical structure development |
Gene expression in normal tissue: WIF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WIF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_signaling_pathway | Wnt signaling network |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WIF1
CLASSFICATION
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