MMP25
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 25 | MIM:608482 | Ensembl:ENSG00000008516 | HGNC:HGNC:14246 | PA30882 | 16p13.3 |
GO terms in MMP25
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| BP | NAS | GO:0006508 | proteolysis |
| BP | NAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0060022 | hard palate development |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | NAS | GO:0031012 | extracellular matrix |
| CC | IEA | GO:0031225 | anchored component of membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
Gene expression in normal tissue: MMP25
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP25
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| wikipathways | WP129 | Matrix Metalloproteinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD425 | ERASTIN | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP25
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