NACA
Summary: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nascent polypeptide associated complex subunit alpha | MIM:601234 | Ensembl:ENSG00000196531 | HGNC:HGNC:7629 | PA31433 | 12q13.3 |
GO terms in NACA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005854 | nascent polypeptide-associated complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
Gene expression in normal tissue: NACA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NACA
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