NACA


Summary: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nascent polypeptide associated complex subunit alphaMIM:601234Ensembl:ENSG00000196531HGNC:HGNC:7629PA3143312q13.3

GO terms in NACA


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003677DNA binding
CCIEAGO:0005634nucleus
CCIEAGO:0005854nascent polypeptide-associated complex
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated

Gene expression in normal tissue: NACA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NACA


DatabasePathway IDPathway Des.
pidilk_pathwayIntegrin-linked kinase signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B3
iGMDRD297Austocystin D3
iGMDRD781Sirolimus3
iGMDRD872BRD71373
iGMDRD341Triacsin c6
iGMDRD48Dexamethasone3
iGMDRD61Kinetin riboside3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NACA

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