SEMA5B
Summary: This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| semaphorin 5B | MIM:609298 | Ensembl:ENSG00000082684 | HGNC:HGNC:10737 | PA35659 | 3q21.1 |
GO terms in SEMA5B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0030215 | semaphorin receptor binding |
| MF | IBA | GO:0045499 | chemorepellent activity |
| BP | IBA | GO:0001755 | neural crest cell migration |
| BP | IBA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0048675 | axon extension |
| BP | IBA | GO:0048843 | negative regulation of axon extension involved in axon guidance |
| BP | IEA | GO:0050908 | detection of light stimulus involved in visual perception |
| BP | IBA | GO:0071526 | semaphorin-plexin signaling pathway |
| BP | IEA | GO:0097485 | neuron projection guidance |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: SEMA5B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEMA5B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5083635 | Defective B3GALTL causes Peters-plus syndrome (PpS) |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEMA5B
CLASSFICATION
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