PRKAR1B
Summary: The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase cAMP-dependent type I regulatory subunit beta | MIM:176911 | Ensembl:ENSG00000188191 | HGNC:HGNC:9390 | PA33756 | 7p22.3 |
GO terms in PRKAR1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| MF | NAS | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| MF | IEA | GO:0030552 | cAMP binding |
| MF | IPI | GO:0034236 | protein kinase A catalytic subunit binding |
| MF | IBA | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| BP | TAS | GO:0003091 | renal water homeostasis |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0007611 | learning or memory |
| BP | IBA | GO:0019934 | cGMP-mediated signaling |
| BP | TAS | GO:0034199 | activation of protein kinase A activity |
| BP | TAS | GO:0071377 | cellular response to glucagon stimulus |
| BP | IDA | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005952 | cAMP-dependent protein kinase complex |
| CC | TAS | GO:0097546 | ciliary base |
Gene expression in normal tissue: PRKAR1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAR1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163359 | Glucagon signaling in metabolic regulation |
| reactome | R-HSA-163615 | PKA activation |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-164378 | PKA activation in glucagon signalling |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins |
| reactome | R-HSA-445717 | Aquaporin-mediated transport |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| biocarta | agpcrpathway | attenuation of gpcr signaling |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | cftrpathway | cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | plcepathway | phospholipase c-epsilon pathway |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAR1B
CLASSFICATION
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