Summary: The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015].

protein kinase cAMP-dependent type I regulatory subunit betaMIM:176911Ensembl:ENSG00000188191HGNC:HGNC:9390PA337567p22.3

GO terms in PRKAR1B

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004862cAMP-dependent protein kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008603cAMP-dependent protein kinase regulator activity
MFNASGO:0008603cAMP-dependent protein kinase regulator activity
MFIEAGO:0030552cAMP binding
MFIPIGO:0034236protein kinase A catalytic subunit binding
MFIBAGO:00475553',5'-cyclic-GMP phosphodiesterase activity
BPTASGO:0003091renal water homeostasis
BPNASGO:0006468protein phosphorylation
BPTASGO:0007596blood coagulation
BPIEAGO:0007611learning or memory
BPIBAGO:0019934cGMP-mediated signaling
BPTASGO:0034199activation of protein kinase A activity
BPTASGO:0071377cellular response to glucagon stimulus
BPIDAGO:2000480negative regulation of cAMP-dependent protein kinase activity
CCIEAGO:0005886plasma membrane
CCNASGO:0005952cAMP-dependent protein kinase complex
CCTASGO:0097546ciliary base

Gene expression in normal tissue: PRKAR1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKAR1B

DatabasePathway IDPathway Des.
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111931PKA-mediated phosphorylation of CREB
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163359Glucagon signaling in metabolic regulation
reactomeR-HSA-163615PKA activation
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-164378PKA activation in glucagon signalling
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-432040Vasopressin regulates renal water homeostasis via Aquaporins
reactomeR-HSA-445717Aquaporin-mediated transport
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
biocartaagpcrpathwayattenuation of gpcr signaling
biocartabadpathwayregulation of bad phosphorylation
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartacftrpathwaycystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartadreampathwayrepression of pain sensation by the transcriptional regulator dream
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartagpcrpathwaysignaling pathway from g-protein families
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamprpathwayhow progesterone initiates the oocyte maturation
biocartano1pathwayactions of nitric oxide in the heart
biocartanos1pathwaynitric oxide signaling pathway
biocartaplcepathwayphospholipase c-epsilon pathway
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAR1B