PRKAR1B

Summary: The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameprotein kinase cAMP-dependent type I regulatory subunit beta
OMIM IDMIM:176911
Ensembl IDEnsembl:ENSG00000188191
HGNC IDHGNC:HGNC:9390
PHARMGKB IDPA33756
Map Location7p22.3

GO terms in PRKAR1B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004862 cAMP-dependent protein kinase inhibitor activity
MF IPI GO:0005515 protein binding
MF IDA GO:0008603 cAMP-dependent protein kinase regulator activity
MF NAS GO:0008603 cAMP-dependent protein kinase regulator activity
MF IEA GO:0030552 cAMP binding
MF IPI GO:0034236 protein kinase A catalytic subunit binding
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Gene expression in normal tissue: PRKAR1B

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 5

Gene-drug pathway distribution

undefined1Longevity regulating pathway1

Pathways in PRKAR1B


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-111885 Opioid Signalling
reactome R-HSA-111931 PKA-mediated phosphorylation of CREB
reactome R-HSA-111933 Calmodulin induced events
reactome R-HSA-111996 Ca-dependent events
reactome R-HSA-111997 CaM pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 2
iGMDRD77 Itraconazole 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAR1B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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