MLLT11
Summary: The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MLLT11, transcription factor 7 cofactor | MIM:604684 | Ensembl:ENSG00000213190 | HGNC:HGNC:16997 | PA142671347 | 1q21.3 |
GO terms in MLLT11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0051901 | positive regulation of mitochondrial depolarization |
| BP | IDA | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IDA | GO:0097193 | intrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: MLLT11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MLLT11
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD577 | BIX01294 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MLLT11
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