MLLT11


Summary: The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008].

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GO terms in MLLT11


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0043065 positive regulation of apoptotic process
BP IDA GO:0045893 positive regulation of transcription, DNA-templated
BP IDA GO:0051901 positive regulation of mitochondrial depolarization
BP IDA GO:0090200 positive regulation of release of cytochrome c from mitochondria
BP IDA GO:0097191 extrinsic apoptotic signaling pathway
BP IDA GO:0097193 intrinsic apoptotic signaling pathway
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Gene expression in normal tissue: MLLT11

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 17BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9

Gene-drug pathway distribution

undefined6Biosynthesis of secondary metabolites1ERK MAPK signaling1Mitosis1Longevity regulating pathway1

Pathways in MLLT11


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 1
iGMDRD484 Pluripotin 2
iGMDRD781 Sirolimus 5
iGMDRD137 Indisulam 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MLLT11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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