Summary: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].

cyclin dependent kinase inhibitor 2DMIM:600927Ensembl:ENSG00000129355HGNC:HGNC:1790PA2632319p13.2

GO terms in CDKN2D

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0097129cyclin D2-CDK4 complex
BPIDAGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPIDAGO:0000082G1/S transition of mitotic cell cycle
BPIMPGO:0000731DNA synthesis involved in DNA repair
BPIDAGO:0007050cell cycle arrest
BPIEAGO:0007605sensory perception of sound
BPIDAGO:0008285negative regulation of cell proliferation
BPIMPGO:0009411response to UV
BPIDAGO:0030308negative regulation of cell growth
BPTASGO:0031658negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
BPIMPGO:0032526response to retinoic acid
BPIMPGO:0033280response to vitamin D
BPIDAGO:0042326negative regulation of phosphorylation
BPIMPGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIMPGO:0048102autophagic cell death
BPIMPGO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:1902807negative regulation of cell cycle G1/S phase transition
MFIBAGO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity
MFIDAGO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: CDKN2D

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDKN2D

DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP45G1 to S cell cycle control
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartag2pathwaycell cycle: g2/m checkpoint
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDKN2D