CDKN2D
Summary: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase inhibitor 2D | MIM:600927 | Ensembl:ENSG00000129355 | HGNC:HGNC:1790 | PA26323 | 19p13.2 |
GO terms in CDKN2D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0097129 | cyclin D2-CDK4 complex |
| BP | IDA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IDA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IMP | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0009411 | response to UV |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | TAS | GO:0031658 | negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle |
| BP | IMP | GO:0032526 | response to retinoic acid |
| BP | IMP | GO:0033280 | response to vitamin D |
| BP | IDA | GO:0042326 | negative regulation of phosphorylation |
| BP | IMP | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0048102 | autophagic cell death |
| BP | IMP | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:1902807 | negative regulation of cell cycle G1/S phase transition |
| MF | IBA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IDA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: CDKN2D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN2D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN2D
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