TRIM28
Summary: The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 28 | MIM:601742 | Ensembl:ENSG00000130726 | HGNC:HGNC:16384 | PA38131 | 19q13.43 |
GO terms in TRIM28
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001837 | epithelial to mesenchymal transition |
| BP | IDA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IMP | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0016925 | protein sumoylation |
| BP | IDA | GO:0016925 | protein sumoylation |
| BP | IEA | GO:0016925 | protein sumoylation |
| BP | IDA | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IEA | GO:0043045 | DNA methylation involved in embryo development |
| BP | IEA | GO:0043388 | positive regulation of DNA binding |
| BP | IDA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045739 | positive regulation of DNA repair |
| BP | IEA | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | IEA | GO:0060028 | convergent extension involved in axis elongation |
| BP | IEA | GO:0060669 | embryonic placenta morphogenesis |
| BP | IMP | GO:0090309 | positive regulation of methylation-dependent chromatin silencing |
| BP | IEA | GO:1901536 | negative regulation of DNA demethylation |
| BP | IDA | GO:1902187 | negative regulation of viral release from host cell |
| BP | IEA | GO:2000653 | regulation of genetic imprinting |
| CC | IBA | GO:0000785 | chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005719 | nuclear euchromatin |
| CC | IEA | GO:0005720 | nuclear heterochromatin |
| CC | IBA | GO:0090575 | RNA polymerase II transcription factor complex |
| CC | ISS | GO:0090575 | RNA polymerase II transcription factor complex |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | ISS | GO:0003700 | DNA-binding transcription factor activity |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0035851 | Krueppel-associated box domain binding |
| MF | ISS | GO:0043565 | sequence-specific DNA binding |
| MF | IPI | GO:0070087 | chromo shadow domain binding |
| MF | IBA | GO:1990841 | promoter-specific chromatin binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: TRIM28
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM28
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| pid | atm_pathway | ATM pathway |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | e2f_pathway | E2F transcription factor network |
| pid | p53regulationpathway | p53 pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD579 | PF750 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD142 | NSC74859 | 1 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD300 | Tozasertib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM28
CLASSFICATION
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