FGF1
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:131220 Ensembl IDEnsembl:ENSG00000113578 HGNC IDHGNC:HGNC:3665 PHARMGKB IDPA28105 Map Location5q31.3 | |||||
GO terms in FGF1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005104 | fibroblast growth factor receptor binding |
| MF | IPI | GO:0005104 | fibroblast growth factor receptor binding |
| MF | IDA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FGF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGF1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | fgf_pathway | FGF signaling pathway |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGF1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.