Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

eukaryotic translation initiation factor 2 alpha kinase 2MIM:176871Ensembl:ENSG00000055332HGNC:HGNC:9437PA337792p22.2

GO terms in EIF2AK2

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIDAGO:0003725double-stranded RNA binding
MFIBAGO:0004672protein kinase activity
MFIDAGO:0004672protein kinase activity
MFIMPGO:0004672protein kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIMPGO:0004694eukaryotic translation initiation factor 2alpha kinase activity
MFIEAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0019888protein phosphatase regulator activity
MFIPIGO:0042802identical protein binding
CCIBAGO:0022626cytosolic ribosome
CCIDAGO:0048471perinuclear region of cytoplasm
BPIMPGO:0000186activation of MAPKK activity
BPISSGO:0001819positive regulation of cytokine production
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006468protein phosphorylation
BPTASGO:0008285negative regulation of cell proliferation
BPIMPGO:0009615response to virus
BPIEAGO:0009636response to toxic substance
BPIEAGO:0010998regulation of translational initiation by eIF2 alpha phosphorylation
BPIDAGO:0017148negative regulation of translation
BPIMPGO:0017148negative regulation of translation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPTASGO:0030683evasion or tolerance by virus of host immune response
BPIEAGO:0030968endoplasmic reticulum unfolded protein response
BPISSGO:0032722positive regulation of chemokine production
BPISSGO:0032874positive regulation of stress-activated MAPK cascade
BPIMPGO:0033689negative regulation of osteoblast proliferation
BPIMPGO:0034198cellular response to amino acid starvation
BPIDAGO:0035455response to interferon-alpha
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043666regulation of phosphoprotein phosphatase activity
BPIMPGO:0045071negative regulation of viral genome replication
BPIEAGO:0045087innate immune response
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0046777protein autophosphorylation
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051607defense response to virus
BPISSGO:1900225regulation of NLRP3 inflammasome complex assembly
BPISSGO:1901224positive regulation of NIK/NF-kappaB signaling
BPISSGO:1901532regulation of hematopoietic progenitor cell differentiation
BPISSGO:1902033regulation of hematopoietic stem cell proliferation
BPISSGO:1902036regulation of hematopoietic stem cell differentiation

Gene expression in normal tissue: EIF2AK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF2AK2

DatabasePathway IDPathway Des.
pidceramide_pathwayCeramide signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidtcptp_pathwaySignaling events mediated by TCPTP
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
wikipathwaysWP107Translation Factors
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP619Type II interferon signaling (IFNG)
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168253Host Interactions with Influenza Factors
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168256Immune System
reactomeR-HSA-168276NS1 Mediated Effects on Host Pathways
reactomeR-HSA-169131Inhibition of PKR
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-913531Interferon Signaling
biocartaeif2pathwayregulation of eif2
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartarnapathwaydouble stranded rna induced gene expression
biocartatollpathwaytoll-like receptor pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF2AK2