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EIF2AK2

Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameeukaryotic translation initiation factor 2 alpha kinase 2 OMIM IDMIM:176871 Ensembl IDEnsembl:ENSG00000055332 HGNC IDHGNC:HGNC:9437 PHARMGKB IDPA33779 Map Location2p22.2

Gene Categories:

KINASE SERINE THREONINE KINASE TYROSINE KINASE DRUGGABLE GENOME PROTEIN PHOSPHATASE

GO terms in EIF2AK2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	HDA	GO:0003723	RNA binding
MF	IDA	GO:0003725	double-stranded RNA binding
MF	IBA	GO:0004672	protein kinase activity
MF	IDA	GO:0004672	protein kinase activity
MF	IMP	GO:0004672	protein kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity

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Gene expression in normal tissue: EIF2AK2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF2AK2

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Database	Pathway ID	Pathway Des.
pid	ceramide_pathway	Ceramide signaling pathway
pid	pdgfrbpathway	PDGFR-beta signaling pathway
pid	tcptp_pathway	Signaling events mediated by TCPTP
kegg	hsa04141	Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg	hsa04217	Necroptosis - Homo sapiens (human)
kegg	hsa05160	Hepatitis C - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD781	Sirolimus	3
iGMDRD506	Fedratinib	1
iGMDRD351	GW843682X	2
iGMDRD61	Kinetin riboside	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF2AK2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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