EIF2AK2
Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 2 alpha kinase 2 | MIM:176871 | Ensembl:ENSG00000055332 | HGNC:HGNC:9437 | PA33779 | 2p22.2 |
GO terms in EIF2AK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IMP | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IEA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0019888 | protein phosphatase regulator activity |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005840 | ribosome |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0022626 | cytosolic ribosome |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IMP | GO:0000186 | activation of MAPKK activity |
| BP | ISS | GO:0001819 | positive regulation of cytokine production |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006412 | translation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0009615 | response to virus |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0010998 | regulation of translational initiation by eIF2 alpha phosphorylation |
| BP | IDA | GO:0017148 | negative regulation of translation |
| BP | IMP | GO:0017148 | negative regulation of translation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0030683 | evasion or tolerance by virus of host immune response |
| BP | IEA | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | ISS | GO:0032722 | positive regulation of chemokine production |
| BP | ISS | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| BP | IMP | GO:0033689 | negative regulation of osteoblast proliferation |
| BP | IMP | GO:0034198 | cellular response to amino acid starvation |
| BP | IDA | GO:0035455 | response to interferon-alpha |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| BP | IMP | GO:0045071 | negative regulation of viral genome replication |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | ISS | GO:1900225 | regulation of NLRP3 inflammasome complex assembly |
| BP | ISS | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | ISS | GO:1901532 | regulation of hematopoietic progenitor cell differentiation |
| BP | ISS | GO:1902033 | regulation of hematopoietic stem cell proliferation |
| BP | ISS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
Gene expression in normal tissue: EIF2AK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2AK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-169131 | Inhibition of PKR |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-913531 | Interferon Signaling |
| biocarta | eif2pathway | regulation of eif2 |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | rnapathway | double stranded rna induced gene expression |
| biocarta | tollpathway | toll-like receptor pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD780 | PP-30 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2AK2
CLASSFICATION
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