TNFRSF1B
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 1B | MIM:191191 | Ensembl:ENSG00000028137 | HGNC:HGNC:11917 | PA36610 | 1p36.22 |
GO terms in TNFRSF1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| BP | ISS | GO:0003176 | aortic valve development |
| BP | ISS | GO:0003177 | pulmonary valve development |
| BP | ISS | GO:0003332 | negative regulation of extracellular matrix constituent secretion |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | IEA | GO:0050779 | RNA destabilization |
| BP | IMP | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | IMP | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071363 | cellular response to growth factor stimulus |
| BP | IEA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | ISS | GO:1902339 | positive regulation of apoptotic process involved in morphogenesis |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043196 | varicosity |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: TNFRSF1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP3945 | TYROBP Causal Network |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP453 | Inflammatory Response Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD872 | BRD7137 | 9 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD871 | BRD6368 | 7 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD201 | SKI II | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF1B
CLASSFICATION
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