NR4A3
Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor subfamily 4 group A member 3 | MIM:600542 | Ensembl:ENSG00000119508 | HGNC:HGNC:7982 | PA31763 | 9q31.1 |
GO terms in NR4A3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001223 | transcription coactivator binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | TAS | GO:0004887 | thyroid hormone receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0035035 | histone acetyltransferase binding |
| MF | IBA | GO:0035259 | glucocorticoid receptor binding |
| MF | IEA | GO:0035259 | glucocorticoid receptor binding |
| MF | ISS | GO:0035497 | cAMP response element binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0042629 | mast cell granule |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | ISS | GO:0007369 | gastrulation |
| BP | IEA | GO:0007411 | axon guidance |
| BP | ISS | GO:0009444 | pyruvate oxidation |
| BP | ISS | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IDA | GO:0010828 | positive regulation of glucose transmembrane transport |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IEA | GO:0030522 | intracellular receptor signaling pathway |
| BP | IEA | GO:0030534 | adult behavior |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | ISS | GO:0032765 | positive regulation of mast cell cytokine production |
| BP | ISS | GO:0035726 | common myeloid progenitor cell proliferation |
| BP | ISS | GO:0038097 | positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | ISS | GO:0043303 | mast cell degranulation |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | ISS | GO:0044320 | cellular response to leptin stimulus |
| BP | ISS | GO:0045333 | cellular respiration |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0046321 | positive regulation of fatty acid oxidation |
| BP | IDA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IDA | GO:0048660 | regulation of smooth muscle cell proliferation |
| BP | ISS | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048752 | semicircular canal morphogenesis |
| BP | ISS | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0050885 | neuromuscular process controlling balance |
| BP | IEA | GO:0060005 | vestibular reflex |
| BP | ISS | GO:0061469 | regulation of type B pancreatic cell proliferation |
| BP | IBA | GO:0071376 | cellular response to corticotropin-releasing hormone stimulus |
| BP | ISS | GO:0071376 | cellular response to corticotropin-releasing hormone stimulus |
| BP | ISS | GO:0071870 | cellular response to catecholamine stimulus |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | IMP | GO:1900625 | positive regulation of monocyte aggregation |
| BP | ISS | GO:1903208 | negative regulation of hydrogen peroxide-induced neuron death |
| BP | IGI | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| BP | IGI | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| BP | IEA | GO:2000108 | positive regulation of leukocyte apoptotic process |
| BP | ISS | GO:2000253 | positive regulation of feeding behavior |
Gene expression in normal tissue: NR4A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR4A3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4132 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| wikipathways | WP516 | Hypertrophy Model |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NR4A3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.