IL2
Summary: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 2 | MIM:147680 | Ensembl:ENSG00000109471 | HGNC:HGNC:6001 | PA195 | 4q27 |
GO terms in IL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0002366 | leukocyte activation involved in immune response |
| BP | IDA | GO:0002903 | negative regulation of B cell apoptotic process |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IEA | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0030101 | natural killer cell activation |
| BP | TAS | GO:0030217 | T cell differentiation |
| BP | TAS | GO:0030307 | positive regulation of cell growth |
| BP | IDA | GO:0030890 | positive regulation of B cell proliferation |
| BP | IEA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IDA | GO:0032740 | positive regulation of interleukin-17 production |
| BP | IC | GO:0034105 | positive regulation of tissue remodeling |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | IDA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IDA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | TAS | GO:0045589 | regulation of regulatory T cell differentiation |
| BP | IEA | GO:0045591 | positive regulation of regulatory T cell differentiation |
| BP | IEA | GO:0045822 | negative regulation of heart contraction |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046013 | regulation of T cell homeostatic proliferation |
| BP | IEA | GO:0048304 | positive regulation of isotype switching to IgG isotypes |
| BP | IEA | GO:0050672 | negative regulation of lymphocyte proliferation |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | IC | GO:0050729 | positive regulation of inflammatory response |
| BP | IEA | GO:0051024 | positive regulation of immunoglobulin secretion |
| BP | IEA | GO:0060999 | positive regulation of dendritic spine development |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IEA | GO:2000320 | negative regulation of T-helper 17 cell differentiation |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005134 | interleukin-2 receptor binding |
| MF | TAS | GO:0005134 | interleukin-2 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008083 | growth factor activity |
| MF | TAS | GO:0019209 | kinase activator activity |
| MF | IEA | GO:0030246 | carbohydrate binding |
| MF | IEA | GO:0031851 | kappa-type opioid receptor binding |
| MF | IEA | GO:0043208 | glycosphingolipid binding |
Gene expression in normal tissue: IL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4079 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP453 | Inflammatory Response Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| pid | telomerasepathway | Regulation of Telomerase |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05330 | Allograft rejection - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_IL2 | IL2 |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD780 | PP-30 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD300 | Tozasertib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL2
CLASSFICATION
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