Summary: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008].

interleukin 2MIM:147680Ensembl:ENSG00000109471HGNC:HGNC:6001PA1954q27

GO terms in IL2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCTASGO:0005615extracellular space
BPTASGO:0000165MAPK cascade
BPIEAGO:0001933negative regulation of protein phosphorylation
BPIEAGO:0002250adaptive immune response
BPIDAGO:0002366leukocyte activation involved in immune response
BPIDAGO:0002903negative regulation of B cell apoptotic process
BPTASGO:0006955immune response
BPTASGO:0007155cell adhesion
BPIEAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIEAGO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPTASGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0030101natural killer cell activation
BPTASGO:0030217T cell differentiation
BPTASGO:0030307positive regulation of cell growth
BPIDAGO:0030890positive regulation of B cell proliferation
BPIEAGO:0032729positive regulation of interferon-gamma production
BPIDAGO:0032740positive regulation of interleukin-17 production
BPICGO:0034105positive regulation of tissue remodeling
BPTASGO:0038110interleukin-2-mediated signaling pathway
BPIDAGO:0042104positive regulation of activated T cell proliferation
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPTASGO:0043066negative regulation of apoptotic process
BPIEAGO:0045471response to ethanol
BPTASGO:0045589regulation of regulatory T cell differentiation
BPIEAGO:0045591positive regulation of regulatory T cell differentiation
BPIEAGO:0045822negative regulation of heart contraction
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046013regulation of T cell homeostatic proliferation
BPIEAGO:0048304positive regulation of isotype switching to IgG isotypes
BPIEAGO:0050672negative regulation of lymphocyte proliferation
BPIEAGO:0050728negative regulation of inflammatory response
BPICGO:0050729positive regulation of inflammatory response
BPIEAGO:0051024positive regulation of immunoglobulin secretion
BPIEAGO:0060999positive regulation of dendritic spine development
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:2000320negative regulation of T-helper 17 cell differentiation
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIDAGO:0005125cytokine activity
MFIDAGO:0005134interleukin-2 receptor binding
MFTASGO:0005134interleukin-2 receptor binding
MFIPIGO:0005515protein binding
MFTASGO:0008083growth factor activity
MFTASGO:0019209kinase activator activity
MFIEAGO:0030246carbohydrate binding
MFIEAGO:0031851kappa-type opioid receptor binding
MFIEAGO:0043208glycosphingolipid binding

Gene expression in normal tissue: IL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL2

DatabasePathway IDPathway Des.
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP176Folate Metabolism
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4079RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP453Inflammatory Response Pathway
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP530Cytokines and Inflammatory Response
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pidap1_pathwayAP-1 transcription factor network
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidil12_2pathwayIL12-mediated signaling events
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil23pathwayIL23-mediated signaling events
pidil27pathwayIL27-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidshp2_pathwaySHP2 signaling
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
pidtelomerasepathwayRegulation of Telomerase
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
biocarta41bbpathwaythe 41bb-dependent immune response
biocartail2pathwayil 2 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-9020558Interleukin-2 signaling
reactomeR-HSA-912526Interleukin receptor SHC signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL2