IL2
Summary: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameinterleukin 2 OMIM IDMIM:147680 Ensembl IDEnsembl:ENSG00000109471 HGNC IDHGNC:HGNC:6001 PHARMGKB IDPA195 Map Location4q27 | |||||
GO terms in IL2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IEA | GO:0002250 | adaptive immune response |
Gene expression in normal tissue: IL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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