HOXA9
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namehomeobox A9 OMIM IDMIM:142956 Ensembl IDEnsembl:ENSG00000078399 HGNC IDHGNC:HGNC:5109 PHARMGKB IDPA29386 Map Location7p15.2 | |||||
GO terms in HOXA9
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IMP | GO:0042118 | endothelial cell activation |
| BP | ISS | GO:0045638 | negative regulation of myeloid cell differentiation |
| CC | IDA | GO:0005634 | nucleus |
Gene expression in normal tissue: HOXA9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXA9
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXA9
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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