PAFAH1B2
Summary: Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| platelet activating factor acetylhydrolase 1b catalytic subunit 2 | MIM:602508 | Ensembl:ENSG00000168092 | HGNC:HGNC:8575 | PA32906 | 11q23.3 |
Gene Categories:
PHOSPHOLIPASEGO terms in PAFAH1B2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| MF | TAS | GO:0004623 | phospholipase A2 activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0047179 | platelet-activating factor acetyltransferase activity |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0007420 | brain development |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | IMP | GO:0016239 | positive regulation of macroautophagy |
| BP | TAS | GO:0043312 | neutrophil degranulation |
Gene expression in normal tissue: PAFAH1B2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAFAH1B2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAFAH1B2
CLASSFICATION
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