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PAFAH1B2

Summary: Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameplatelet activating factor acetylhydrolase 1b catalytic subunit 2 OMIM IDMIM:602508 Ensembl IDEnsembl:ENSG00000168092 HGNC IDHGNC:HGNC:8575 PHARMGKB IDPA32906 Map Location11q23.3

Gene Categories:

PHOSPHOLIPASE

GO terms in PAFAH1B2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
MF	TAS	GO:0004623	phospholipase A2 activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0042803	protein homodimerization activity
MF	IEA	GO:0046982	protein heterodimerization activity
MF	IBA	GO:0047179	platelet-activating factor acetyltransferase activity

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Gene expression in normal tissue: PAFAH1B2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAFAH1B2

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Database	Pathway ID	Pathway Des.
kegg	hsa00565	Ether lipid metabolism - Homo sapiens (human)
pid	lis1pathway	Lissencephaly gene (LIS1) in neuronal migration and development
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD297	Austocystin D	3
iGMDRD562	Navitoclax	3
iGMDRD61	Kinetin riboside	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAFAH1B2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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