PPP3R1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 3 regulatory subunit B, alpha | MIM:601302 | Ensembl:ENSG00000221823 | HGNC:HGNC:9317 | PA33681 | 2p14 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PPP3R1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0016018 | cyclosporin A binding |
| MF | IPI | GO:0019902 | phosphatase binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005955 | calcineurin complex |
| CC | NAS | GO:0005955 | calcineurin complex |
| CC | IEA | GO:0042383 | sarcolemma |
| BP | IEA | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | IEA | GO:0001837 | epithelial to mesenchymal transition |
| BP | IEA | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0006606 | protein import into nucleus |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0022011 | myelination in peripheral nervous system |
| BP | IDA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0060487 | lung epithelial cell differentiation |
Gene expression in normal tissue: PPP3R1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP3R1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111447 | Activation of BAD and translocation to mitochondria |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-2025928 | Calcineurin activates NFAT |
| reactome | R-HSA-2025928 | Calcineurin activates NFAT |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1559 | TFs Regulate miRNAs related to cardiac hypertrophy |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP3R1
CLASSFICATION
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