SOST
Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sclerostin | MIM:605740 | Ensembl:ENSG00000167941 | HGNC:HGNC:13771 | PA37809 | 17q21.31 |
GO terms in SOST
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001503 | ossification |
| BP | IEP | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0030279 | negative regulation of ossification |
| BP | IDA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IDA | GO:0031333 | negative regulation of protein complex assembly |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0071374 | cellular response to parathyroid hormone stimulus |
| BP | IDA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008201 | heparin binding |
Gene expression in normal tissue: SOST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOST
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD154 | NSC23766 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOST
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