SOST
Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namesclerostin OMIM IDMIM:605740 Ensembl IDEnsembl:ENSG00000167941 HGNC IDHGNC:HGNC:13771 PHARMGKB IDPA37809 Map Location17q21.31 | |||||
GO terms in SOST
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001503 | ossification |
| BP | IEP | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0030279 | negative regulation of ossification |
| BP | IDA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IDA | GO:0031333 | negative regulation of protein complex assembly |
Gene expression in normal tissue: SOST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOST
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOST
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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