MAP4K1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase kinase 1 | MIM:601983 | Ensembl:ENSG00000104814 | HGNC:HGNC:6863 | PA30609 | 19q13.2 |
GO terms in MAP4K1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IC | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007257 | activation of JUN kinase activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate |
| CC | IC | GO:0005622 | intracellular |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0016020 | membrane |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008349 | MAP kinase kinase kinase kinase activity |
| MF | IDA | GO:0008349 | MAP kinase kinase kinase kinase activity |
Gene expression in normal tissue: MAP4K1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP4K1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mapkpathway | mapkinase signaling pathway |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD690 | PRIMA-1MET | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP4K1
CLASSFICATION
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