EEF1D
Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation elongation factor 1 delta | MIM:130592 | Ensembl:ENSG00000104529 | HGNC:HGNC:3211 | PA27647 | 8q24.3 |
GO terms in EEF1D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003746 | translation elongation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008135 | translation factor activity, RNA binding |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005853 | eukaryotic translation elongation factor 1 complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006414 | translational elongation |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0071479 | cellular response to ionizing radiation |
Gene expression in normal tissue: EEF1D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EEF1D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72766 | Translation |
| wikipathways | WP107 | Translation Factors |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD116 | CD437 | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EEF1D
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