EEF1D
Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:130592 Ensembl IDEnsembl:ENSG00000104529 HGNC IDHGNC:HGNC:3211 PHARMGKB IDPA27647 Map Location8q24.3 | |||||
GO terms in EEF1D
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003746 | translation elongation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008135 | translation factor activity, RNA binding |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | IDA | GO:0001650 | fibrillar center |
Gene expression in normal tissue: EEF1D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EEF1D
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72766 | Translation |
| wikipathways | WP107 | Translation Factors |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EEF1D
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.