AURKB


Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
aurora kinase BMIM:604970Ensembl:ENSG00000178999HGNC:HGNC:11390PA3619917p13.1

GO terms in AURKB


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0002903negative regulation of B cell apoptotic process
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0007051spindle organization
BPIBAGO:0007052mitotic spindle organization
BPIEAGO:0007568aging
BPIEAGO:0008283cell proliferation
BPTASGO:0008608attachment of spindle microtubules to kinetochore
BPISSGO:0009838abscission
BPTASGO:0016570histone modification
BPTASGO:0031145anaphase-promoting complex-dependent catabolic process
BPIEAGO:0031577spindle checkpoint
BPIDAGO:0032091negative regulation of protein binding
BPIMPGO:0032212positive regulation of telomere maintenance via telomerase
BPIBAGO:0032465regulation of cytokinesis
BPISSGO:0032466negative regulation of cytokinesis
BPIMPGO:0032467positive regulation of cytokinesis
BPTASGO:0032467positive regulation of cytokinesis
BPIMPGO:0034501protein localization to kinetochore
BPIDAGO:0034644cellular response to UV
BPIDAGO:0036089cleavage furrow formation
BPISSGO:0043988histone H3-S28 phosphorylation
BPISSGO:0044878mitotic cytokinesis checkpoint
BPTASGO:0046777protein autophosphorylation
BPIMPGO:0051256mitotic spindle midzone assembly
BPTASGO:0051256mitotic spindle midzone assembly
BPIMPGO:0051973positive regulation of telomerase activity
BPTASGO:0051983regulation of chromosome segregation
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIMPGO:1904355positive regulation of telomere capping
CCIDAGO:0000776kinetochore
CCIDAGO:0000779condensed chromosome, centromeric region
CCIBAGO:0000780condensed nuclear chromosome, centromeric region
CCIDAGO:0000780condensed nuclear chromosome, centromeric region
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCTASGO:0005819spindle
CCTASGO:0005829cytosol
CCIBAGO:0005876spindle microtubule
CCIEAGO:0010369chromocenter
CCIDAGO:0030496midbody
CCTASGO:0030496midbody
CCIBAGO:0031616spindle pole centrosome
CCIBAGO:0032133chromosome passenger complex
CCIPIGO:0032133chromosome passenger complex
CCTASGO:0032133chromosome passenger complex
CCIBAGO:0051233spindle midzone
CCIEAGO:1990023mitotic spindle midzone
MFEXPGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004712protein serine/threonine/tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019900kinase binding
MFIBAGO:0035174histone serine kinase activity
MFISSGO:0035174histone serine kinase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: AURKB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AURKB


DatabasePathway IDPathway Des.
reactomeR-HSA-141424Amplification of signal from the kinetochores
reactomeR-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69618Mitotic Spindle Checkpoint
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
pidaurora_a_pathwayAurora A signaling
pidaurora_b_pathwayAurora B signaling
pidaurora_c_pathwayAurora C signaling
pidfoxm1pathwayFOXM1 transcription factor network
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP3878ATM Signaling Network in Development and Disease

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 126
iGMDRD5Tyrphostin AG 14783
iGMDRD8024-methylfasudil3
iGMDRD782DC-45-A23
iGMDRD289Parthenolide6
iGMDRD267Oligomycin A6
iGMDRD188Piperlongumine4
iGMDRD562Navitoclax3
iGMDRD300Tozasertib3
iGMDRD330BRD41321
iGMDRD126Tipifarnib1
iGMDRD599Salermide6
iGMDRD424Tamatinib3
iGMDRD144NSC953973
iGMDRD85Ursolic acid3
iGMDRD394BX-7953
iGMDRD511CHEMBL3993793

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AURKB

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