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AURKB

Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameaurora kinase B OMIM IDMIM:604970 Ensembl IDEnsembl:ENSG00000178999 HGNC IDHGNC:HGNC:11390 PHARMGKB IDPA36199 Map Location17p13.1

Gene Categories:

CLINICALLY ACTIONABLE RNA DIRECTED DNA POLYMERASE TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE DRUGGABLE GENOME HISTONE MODIFICATION

GO terms in AURKB

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IDA	GO:0002903	negative regulation of B cell apoptotic process
BP	IDA	GO:0006468	protein phosphorylation
BP	IMP	GO:0007051	spindle organization
BP	IBA	GO:0007052	mitotic spindle organization
BP	IEA	GO:0007568	aging

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Gene expression in normal tissue: AURKB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AURKB

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-141424	Amplification of signal from the kinetochores
reactome	R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-174143	APC/C-mediated degradation of cell cycle proteins
reactome	R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD138	PX 12	6
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD802	4-methylfasudil	3
iGMDRD782	DC-45-A2	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AURKB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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