AURKB
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aurora kinase B | MIM:604970 | Ensembl:ENSG00000178999 | HGNC:HGNC:11390 | PA36199 | 17p13.1 |
GO terms in AURKB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0002903 | negative regulation of B cell apoptotic process |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0007051 | spindle organization |
| BP | IBA | GO:0007052 | mitotic spindle organization |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | TAS | GO:0008608 | attachment of spindle microtubules to kinetochore |
| BP | ISS | GO:0009838 | abscission |
| BP | TAS | GO:0016570 | histone modification |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IEA | GO:0031577 | spindle checkpoint |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | IBA | GO:0032465 | regulation of cytokinesis |
| BP | ISS | GO:0032466 | negative regulation of cytokinesis |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | TAS | GO:0032467 | positive regulation of cytokinesis |
| BP | IMP | GO:0034501 | protein localization to kinetochore |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IDA | GO:0036089 | cleavage furrow formation |
| BP | ISS | GO:0043988 | histone H3-S28 phosphorylation |
| BP | ISS | GO:0044878 | mitotic cytokinesis checkpoint |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0051256 | mitotic spindle midzone assembly |
| BP | TAS | GO:0051256 | mitotic spindle midzone assembly |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | TAS | GO:0051983 | regulation of chromosome segregation |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0000779 | condensed chromosome, centromeric region |
| CC | IBA | GO:0000780 | condensed nuclear chromosome, centromeric region |
| CC | IDA | GO:0000780 | condensed nuclear chromosome, centromeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005876 | spindle microtubule |
| CC | IEA | GO:0010369 | chromocenter |
| CC | IDA | GO:0030496 | midbody |
| CC | TAS | GO:0030496 | midbody |
| CC | IBA | GO:0031616 | spindle pole centrosome |
| CC | IBA | GO:0032133 | chromosome passenger complex |
| CC | IPI | GO:0032133 | chromosome passenger complex |
| CC | TAS | GO:0032133 | chromosome passenger complex |
| CC | IBA | GO:0051233 | spindle midzone |
| CC | IEA | GO:1990023 | mitotic spindle midzone |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IBA | GO:0035174 | histone serine kinase activity |
| MF | ISS | GO:0035174 | histone serine kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: AURKB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AURKB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | aurora_b_pathway | Aurora B signaling |
| pid | aurora_c_pathway | Aurora C signaling |
| pid | foxm1pathway | FOXM1 transcription factor network |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD267 | Oligomycin A | 6 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AURKB
CLASSFICATION
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