TRADD


Summary: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TNFRSF1A associated via death domainMIM:603500Ensembl:ENSG00000102871HGNC:HGNC:12030PA3670716q22.1

Gene Categories:

PROTEASE

GO terms in TRADD


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCIDAGO:0005886plasma membrane
CCTASGO:0031264death-inducing signaling complex
CCIDAGO:0043235receptor complex
CCIEAGO:0045121membrane raft
BPTASGO:0006915apoptotic process
BPTASGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0007165signal transduction
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0043065positive regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051291protein heterooligomerization
BPIEAGO:0051798positive regulation of hair follicle development
BPTASGO:0071550death-inducing signaling complex assembly
BPIMPGO:0097191extrinsic apoptotic signaling pathway
BPTASGO:0097191extrinsic apoptotic signaling pathway
BPTASGO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
MFIEAGO:0005164tumor necrosis factor receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0019900kinase binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0044877protein-containing complex binding
MFIPIGO:0060090molecular adaptor activity
MFIPIGO:0070513death domain binding

Gene expression in normal tissue: TRADD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRADD


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-140534via Death Receptors in the presence of ligand
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-3371378Regulation by c-FLIP
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5218900CASP8 activity is inhibited
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357786TNFR1-induced proapoptotic signaling
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-69416Dimerization of procaspase-8
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
biocartaceramidepathwayceramide signaling pathway
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartanfkbpathwaynf-kb signaling pathway
biocartasoddpathwaysodd/tnfr1 signaling pathway
biocartastresspathwaytnf/stress related signaling
biocartatnfr1pathwaytnfr1 signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidceramide_pathwayCeramide signaling pathway
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidtnfpathwayTNF receptor signaling pathway
pidtrail_pathwayTRAIL signaling pathway
netpathPathway_TNFalphaTNFalpha
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2513Nanoparticle triggered regulated necrosis
wikipathwaysWP254Apoptosis
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP400p38 MAPK Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD248BRD43543
iGMDRD532Olaparib3
iGMDRD872BRD71373
iGMDRD871BRD63683
iGMDRD562Navitoclax3
iGMDRD314Tanespimycin3
iGMDRD300Tozasertib3
iGMDRD451Serdemetan3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRADD

​​​​