TPM4


Summary: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tropomyosin 4MIM:600317Ensembl:ENSG00000167460HGNC:HGNC:12013PA3669319p13.12-p13.11

GO terms in TPM4


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFTASGO:0008307structural constituent of muscle
MFISSGO:0042802identical protein binding
MFISSGO:0042803protein homodimerization activity
MFISSGO:0046982protein heterodimerization activity
MFIBAGO:0051015actin filament binding
MFISSGO:0051015actin filament binding
BPHDAGO:0001649osteoblast differentiation
BPIBAGO:0006936muscle contraction
BPTASGO:0006936muscle contraction
BPIBAGO:0007015actin filament organization
BPTASGO:0030049muscle filament sliding
CCIDAGO:0001725stress fiber
CCTASGO:0005829cytosol
CCTASGO:0005856cytoskeleton
CCTASGO:0005862muscle thin filament tropomyosin
CCIBAGO:0005884actin filament
CCHDAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: TPM4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TPM4


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP383Striated Muscle Contraction
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
reactomeR-HSA-390522Striated Muscle Contraction
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-445355Smooth Muscle Contraction

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22063
iGMDRD424Tamatinib6
iGMDRD144NSC953975
iGMDRD481Dactolisib6
iGMDRD126Tipifarnib1
iGMDRD1008SR-II-138A3
iGMDRD64Parbendazole3
iGMDRD506Fedratinib6
iGMDRD398Sepantronium3
iGMDRD193Fqi11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TPM4

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