TPM4
Summary: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tropomyosin 4 | MIM:600317 | Ensembl:ENSG00000167460 | HGNC:HGNC:12013 | PA36693 | 19p13.12-p13.11 |
GO terms in TPM4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008307 | structural constituent of muscle |
| MF | ISS | GO:0042802 | identical protein binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0051015 | actin filament binding |
| MF | ISS | GO:0051015 | actin filament binding |
| BP | HDA | GO:0001649 | osteoblast differentiation |
| BP | IBA | GO:0006936 | muscle contraction |
| BP | TAS | GO:0006936 | muscle contraction |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | TAS | GO:0030049 | muscle filament sliding |
| CC | IDA | GO:0001725 | stress fiber |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | TAS | GO:0005862 | muscle thin filament tropomyosin |
| CC | IBA | GO:0005884 | actin filament |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: TPM4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TPM4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP383 | Striated Muscle Contraction |
| kegg | hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| reactome | R-HSA-390522 | Striated Muscle Contraction |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD481 | Dactolisib | 6 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD193 | Fqi1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TPM4
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.