RPS6KA1

Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribosomal protein S6 kinase A1
OMIM IDMIM:601684
Ensembl IDEnsembl:ENSG00000117676
HGNC IDHGNC:HGNC:10430
PHARMGKB IDPA34845
Map Location1p36.11

GO terms in RPS6KA1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding
MF IDA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004711 ribosomal protein S6 kinase activity
MF IDA GO:0004712 protein serine/threonine/tyrosine kinase activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: RPS6KA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined13Apoptosis regulation1Chromatin histone acetylation1Other, kinases1Biosynthesis of secondary metabolites1

Pathways in RPS6KA1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD297 Austocystin D 1
iGMDRD85 Ursolic acid 3
iGMDRD57 Chloropentafluorobenzene 3
iGMDRD424 Tamatinib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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