RPS6KA1
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S6 kinase A1 | MIM:601684 | Ensembl:ENSG00000117676 | HGNC:HGNC:10430 | PA34845 | 1p36.11 |
GO terms in RPS6KA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004711 | ribosomal protein S6 kinase activity |
| MF | IDA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IDA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0030307 | positive regulation of cell growth |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0043555 | regulation of translation in response to stress |
| BP | TAS | GO:0043620 | regulation of DNA-templated transcription in response to stress |
| BP | TAS | GO:0045597 | positive regulation of cell differentiation |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0072574 | hepatocyte proliferation |
| BP | IMP | GO:2000491 | positive regulation of hepatic stellate cell activation |
Gene expression in normal tissue: RPS6KA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-199920 | CREB phosphorylation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-444257 | RSK activation |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | melanocytepathway | melanocyte development and pigmentation pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| pid | fgf_pathway | FGF signaling pathway |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | mtor_4pathway | mTOR signaling pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_RAGE | RAGE |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3945 | TYROBP Causal Network |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KA1
CLASSFICATION
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