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FASTK

Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Fas activated serine/threonine kinase	MIM:606965	Ensembl:ENSG00000164896	HGNC:HGNC:24676	PA142671775	7q36.1

Gene Categories:

SERINE THREONINE KINASE KINASE DRUGGABLE GENOME

GO terms in FASTK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003723	RNA binding
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0033867	Fas-activated serine/threonine kinase activity
CC	IEA	GO:0005759	mitochondrial matrix
BP	IDA	GO:0006468	protein phosphorylation
BP	IDA	GO:0043484	regulation of RNA splicing
BP	IMP	GO:0043484	regulation of RNA splicing
BP	TAS	GO:0097190	apoptotic signaling pathway

Gene expression in normal tissue: FASTK

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FASTK

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD126	Tipifarnib	2
iGMDRD882	CIL41	3
iGMDRD424	Tamatinib	2
iGMDRD885	Compound 110	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FASTK

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.