FASTK
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Fas activated serine/threonine kinase | MIM:606965 | Ensembl:ENSG00000164896 | HGNC:HGNC:24676 | PA142671775 | 7q36.1 |
GO terms in FASTK
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003723 | RNA binding |
MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IEA | GO:0033867 | Fas-activated serine/threonine kinase activity |
CC | IEA | GO:0005759 | mitochondrial matrix |
BP | IDA | GO:0006468 | protein phosphorylation |
BP | IDA | GO:0043484 | regulation of RNA splicing |
BP | IMP | GO:0043484 | regulation of RNA splicing |
BP | TAS | GO:0097190 | apoptotic signaling pathway |
Gene expression in normal tissue: FASTK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FASTK
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD126 | Tipifarnib | 2 |
iGMDRD882 | CIL41 | 3 |
iGMDRD424 | Tamatinib | 2 |
iGMDRD885 | Compound 110 | 3 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in FASTK