FASTK


Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in FASTK


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003723 RNA binding
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IEA GO:0033867 Fas-activated serine/threonine kinase activity
CC IEA GO:0005759 mitochondrial matrix
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Gene expression in normal tissue: FASTK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

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Pathways in FASTK


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD126 Tipifarnib 2
iGMDRD882 CIL41 3
iGMDRD424 Tamatinib 2
iGMDRD885 Compound 110 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FASTK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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