HOXD11


Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeobox D11MIM:142986Ensembl:ENSG00000128713HGNC:HGNC:5134PA294082q31.1

GO terms in HOXD11


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0043565sequence-specific DNA binding
CCIDAGO:0005654nucleoplasm
BPISSGO:0001658branching involved in ureteric bud morphogenesis
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPISSGO:0009953dorsal/ventral pattern formation

Gene expression in normal tissue: HOXD11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HOXD11


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD506Fedratinib1
iGMDRD280CYTOCHALASIN B3
iGMDRD154NSC237663
iGMDRD137Indisulam3
iGMDRD1008SR-II-138A1
iGMDRD579PF7502
iGMDRD546BMS-7548073
iGMDRD424Tamatinib1
iGMDRD192CIL563
iGMDRD434BMS-5369243
iGMDRD77Itraconazole3
iGMDRD494Neopeltolide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXD11

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