HOXD11
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox D11 | MIM:142986 | Ensembl:ENSG00000128713 | HGNC:HGNC:5134 | PA29408 | 2q31.1 |
GO terms in HOXD11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| BP | ISS | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0009953 | dorsal/ventral pattern formation |
Gene expression in normal tissue: HOXD11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXD11
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD494 | Neopeltolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXD11
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