ERG
Summary: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ERG, ETS transcription factor | MIM:165080 | Ensembl:ENSG00000157554 | HGNC:HGNC:3446 | PA27858 | 21q22.2 |
GO terms in ERG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| BP | IEA | GO:0003197 | endocardial cushion development |
| BP | IEA | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0016477 | cell migration |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:2000504 | positive regulation of blood vessel remodeling |
Gene expression in normal tissue: ERG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| wikipathways | WP1992 | TarBasePathway |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD192 | CIL56 | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERG
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