CHRNA5
Summary: The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cholinergic receptor nicotinic alpha 5 subunit | MIM:118505 | Ensembl:ENSG00000169684 | HGNC:HGNC:1959 | PA26491 | 15q25.1 |
GO terms in CHRNA5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005892 | acetylcholine-gated channel complex |
| CC | IC | GO:0005892 | acetylcholine-gated channel complex |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0045202 | synapse |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| BP | IBA | GO:0007165 | signal transduction |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0007271 | synaptic transmission, cholinergic |
| BP | IBA | GO:0007274 | neuromuscular synaptic transmission |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0035094 | response to nicotine |
| BP | IMP | GO:0035095 | behavioral response to nicotine |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0050877 | nervous system process |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| MF | IBA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015464 | acetylcholine receptor activity |
| MF | IDA | GO:0015464 | acetylcholine receptor activity |
| MF | NAS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | TAS | GO:0022848 | acetylcholine-gated cation-selective channel activity |
| MF | IBA | GO:0042166 | acetylcholine binding |
Gene expression in normal tissue: CHRNA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRNA5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-181431 | Acetylcholine binding and downstream events |
| reactome | R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| reactome | R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors |
| reactome | R-HSA-629602 | Activation of Nicotinic Acetylcholine Receptors |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| pharmgkb | PA162355621 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
| wikipathways | WP1602 | Nicotine Activity on Dopaminergic Neurons |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD434 | BMS-536924 | 8 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD137 | Indisulam | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHRNA5
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.