CHRNA5

Summary: The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecholinergic receptor nicotinic alpha 5 subunit
OMIM IDMIM:118505
Ensembl IDEnsembl:ENSG00000169684
HGNC IDHGNC:HGNC:1959
PHARMGKB IDPA26491
Map Location15q25.1

GO terms in CHRNA5


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC IBA GO:0005892 acetylcholine-gated channel complex
CC IC GO:0005892 acetylcholine-gated channel complex
CC IEA GO:0030054 cell junction
CC IBA GO:0043005 neuron projection
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Gene expression in normal tissue: CHRNA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHRNA5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-181431 Acetylcholine binding and downstream events
reactome R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
reactome R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD369 TGX-115 3
iGMDRD280 CYTOCHALASIN B 2
iGMDRD60 Quinoclamine 3
iGMDRD23 Gossypol 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHRNA5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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