FNBP1
Summary: The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| formin binding protein 1 | MIM:606191 | Ensembl:ENSG00000187239 | HGNC:HGNC:17069 | PA128394597 | 9q34.11 |
GO terms in FNBP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IEA | GO:0005764 | lysosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005905 | clathrin-coated pit |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| BP | IEA | GO:0006897 | endocytosis |
| BP | TAS | GO:0061024 | membrane organization |
Gene expression in normal tissue: FNBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FNBP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD193 | Fqi1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FNBP1
CLASSFICATION
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