Summary: This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].

interferon beta 1MIM:147640Ensembl:ENSG00000171855HGNC:HGNC:5434PA296729p21.3

Gene Categories:


GO terms in IFNB1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFIBAGO:0005132type I interferon receptor binding
MFNASGO:0005132type I interferon receptor binding
MFIMPGO:0008811chloramphenicol O-acetyltransferase activity
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
BPIBAGO:0002250adaptive immune response
BPIBAGO:0002286T cell activation involved in immune response
BPIMPGO:0002312B cell activation involved in immune response
BPIBAGO:0002323natural killer cell activation involved in immune response
BPIBAGO:0006959humoral immune response
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007596blood coagulation
BPNASGO:0009615response to virus
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0019221cytokine-mediated signaling pathway
BPNASGO:0030101natural killer cell activation
BPIBAGO:0030183B cell differentiation
BPIBAGO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein
BPIDAGO:0033141positive regulation of peptidyl-serine phosphorylation of STAT protein
BPIDAGO:0035458cellular response to interferon-beta
BPIBAGO:0042100B cell proliferation
BPNASGO:0042100B cell proliferation
BPIBAGO:0043330response to exogenous dsRNA
BPIDAGO:0043330response to exogenous dsRNA
BPIDAGO:0045071negative regulation of viral genome replication
BPNASGO:0045089positive regulation of innate immune response
BPNASGO:0045343regulation of MHC class I biosynthetic process
BPIDAGO:0045581negative regulation of T cell differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0051607defense response to virus
BPIDAGO:0060337type I interferon signaling pathway
BPTASGO:0060337type I interferon signaling pathway
BPTASGO:0071360cellular response to exogenous dsRNA
BPIDAGO:2000552negative regulation of T-helper 2 cell cytokine production
BPIDAGO:2001235positive regulation of apoptotic signaling pathway

Gene expression in normal tissue: IFNB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IFNB1

DatabasePathway IDPathway Des.
wikipathwaysWP12Osteoclast Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP3851TLR4 Signaling and Tolerance
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP530Cytokines and Inflammatory Response
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP619Type II interferon signaling (IFNG)
wikipathwaysWP75Toll-like Receptor Signaling Pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
biocartaifnapathwayifn alpha signaling pathway
biocartail1rpathwaysignal transduction through il1r
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
biocartaranklpathwaybone remodeling
biocartarnapathwaydouble stranded rna induced gene expression
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-912694Regulation of IFNA signaling
reactomeR-HSA-912694Regulation of IFNA signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-918233TRAF3-dependent IRF activation pathway
reactomeR-HSA-933541TRAF6 mediated IRF7 activation
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD889Compound 7d-cis3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IFNB1