IFNB1

Summary: This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinterferon beta 1
OMIM IDMIM:147640
Ensembl IDEnsembl:ENSG00000171855
HGNC IDHGNC:HGNC:5434
PHARMGKB IDPA29672
Map Location9p21.3

Gene Categories:

DRUGGABLE GENOME

GO terms in IFNB1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005125 cytokine activity
MF IDA GO:0005125 cytokine activity
MF IBA GO:0005132 type I interferon receptor binding
MF NAS GO:0005132 type I interferon receptor binding
MF IMP GO:0008811 chloramphenicol O-acetyltransferase activity
CC TAS GO:0005576 extracellular region
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Gene expression in normal tissue: IFNB1

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 12undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3

Gene-drug pathway distribution

undefined9Other, kinases1Chromatin histone acetylation1

Pathways in IFNB1


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Database
Pathway ID
Pathway Des.
wikipathways WP12 Osteoclast Signaling
wikipathways WP1449 Regulation of toll-like receptor signaling pathway
wikipathways WP262 EBV LMP1 signaling
wikipathways WP3851 TLR4 Signaling and Tolerance
wikipathways WP3865 RIG-I-like Receptor Signaling
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD210 AC55649 3
iGMDRD889 Compound 7d-cis 3
iGMDRD579 PF750 3
iGMDRD289 Parthenolide 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IFNB1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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