PTTG1


Summary: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].

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GO terms in PTTG1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IMP GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF TAS GO:0003700 DNA-binding transcription factor activity
MF NAS GO:0004869 cysteine-type endopeptidase inhibitor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0017124 SH3 domain binding
MF IBA GO:0030414 peptidase inhibitor activity
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Gene expression in normal tissue: PTTG1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8

Gene-drug pathway distribution

undefined5Mitosis1Other, kinases1

Pathways in PTTG1


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Database
Pathway ID
Pathway Des.
wikipathways WP179 Cell Cycle
wikipathways WP4240 Regulation of sister chromatid separation at the metaphase-anaphase transition
kegg hsa04110 Cell cycle - Homo sapiens (human)
kegg hsa04114 Oocyte meiosis - Homo sapiens (human)
kegg hsa05166 HTLV-I infection - Homo sapiens (human)
reactome R-HSA-1640170 Cell Cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD506 Fedratinib 4
iGMDRD269 Purmorphamine 3
iGMDRD579 PF750 3
iGMDRD126 Tipifarnib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTTG1

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Reference ID
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Cancer
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