PTTG1
Summary: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pituitary tumor-transforming 1 | MIM:604147 | Ensembl:ENSG00000164611 | HGNC:HGNC:9690 | PA34033 | 5q33.3 |
GO terms in PTTG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | NAS | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IBA | GO:0030414 | peptidase inhibitor activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IBA | GO:0045143 | homologous chromosome segregation |
| BP | IEA | GO:0051276 | chromosome organization |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:2000816 | negative regulation of mitotic sister chromatid separation |
Gene expression in normal tissue: PTTG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTTG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP4240 | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD424 | Tamatinib | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTTG1
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