SMAD7

Summary: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSMAD family member 7
OMIM IDMIM:602932
Ensembl IDEnsembl:ENSG00000101665
HGNC IDHGNC:HGNC:6773
PHARMGKB IDPA134875286
Map Location18q21.1

GO terms in SMAD7


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0001650 fibrillar center
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0005667 transcription factor complex
CC IDA GO:0005737 cytoplasm
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Gene expression in normal tissue: SMAD7

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 17BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3

Gene-drug pathway distribution

undefined6Apoptosis regulation1Other, kinases1

Pathways in SMAD7


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-170834 Signaling by TGF-beta Receptor Complex
reactome R-HSA-170834 Signaling by TGF-beta Receptor Complex
reactome R-HSA-201451 Signaling by BMP
reactome R-HSA-212436 Generic Transcription Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 5
iGMDRD147 Prima-1 1
iGMDRD506 Fedratinib 1
iGMDRD398 Sepantronium 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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