HOXA13
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox A13 | MIM:142959 | Ensembl:ENSG00000106031 | HGNC:HGNC:5102 | PA29379 | 7p15.2 |
GO terms in HOXA13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IMP | GO:0043565 | sequence-specific DNA binding |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: HOXA13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXA13
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD210 | AC55649 | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD945 | ML214 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXA13
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