TNFSF10
Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF superfamily member 10 | MIM:603598 | Ensembl:ENSG00000121858 | HGNC:HGNC:11925 | PA36618 | 3q26.31 |
GO terms in TNFSF10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0032868 | response to insulin |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | TAS | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IDA | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IEA | GO:0045569 | TRAIL binding |
Gene expression in normal tissue: TNFSF10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFSF10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | trail_pathway | TRAIL signaling pathway |
| wikipathways | WP1742 | TP53 Network |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5218900 | CASP8 activity is inhibited |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-69416 | Dimerization of procaspase-8 |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75158 | TRAIL signaling |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD329 | Merck60 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFSF10
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