TNFSF10


Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TNF superfamily member 10MIM:603598Ensembl:ENSG00000121858HGNC:HGNC:11925PA366183q26.31

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in TNFSF10


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006915apoptotic process
BPTASGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0006955immune response
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPIEAGO:0008584male gonad development
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0032868response to insulin
BPIDAGO:0043065positive regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0090200positive regulation of release of cytochrome c from mitochondria
BPTASGO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIDAGO:2001238positive regulation of extrinsic apoptotic signaling pathway
CCTASGO:0005576extracellular region
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0070062extracellular exosome
MFTASGO:0005102signaling receptor binding
MFIEAGO:0005125cytokine activity
MFIEAGO:0005164tumor necrosis factor receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0008270zinc ion binding
MFIDAGO:0042802identical protein binding
MFIEAGO:0045569TRAIL binding

Gene expression in normal tissue: TNFSF10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFSF10


DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidtrail_pathwayTRAIL signaling pathway
wikipathwaysWP1742TP53 Network
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP254Apoptosis
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-140534via Death Receptors in the presence of ligand
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-3371378Regulation by c-FLIP
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5218900CASP8 activity is inhibited
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-69416Dimerization of procaspase-8
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75158TRAIL signaling
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369242
iGMDRD885Compound 1105
iGMDRD679Bistramide A1
iGMDRD887Compound 23 citrate2
iGMDRD872BRD71373
iGMDRD506Fedratinib3
iGMDRD577BIX012942
iGMDRD329Merck602

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFSF10

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