LSP1
Summary: This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lymphocyte specific protein 1 | MIM:153432 | Ensembl:ENSG00000130592 | HGNC:HGNC:6707 | PA30472 | 11p15.5 |
GO terms in LSP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | IEA | GO:0007165 | signal transduction |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: LSP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LSP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD158 | NSC141540 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LSP1
CLASSFICATION
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