LSP1
Summary: This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:153432 Ensembl IDEnsembl:ENSG00000130592 HGNC IDHGNC:HGNC:6707 PHARMGKB IDPA30472 Map Location11p15.5 | |||||
GO terms in LSP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | IEA | GO:0007165 | signal transduction |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: LSP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LSP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LSP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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