CSF2

Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecolony stimulating factor 2
OMIM IDMIM:138960
Ensembl IDEnsembl:ENSG00000164400
HGNC IDHGNC:HGNC:2434
PHARMGKB IDPA26937
Map Location5q31.1

GO terms in CSF2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IBA GO:0005615 extracellular space
CC IDA GO:0005615 extracellular space
CC IDA GO:0043231 intracellular membrane-bounded organelle
BP TAS GO:0000165 MAPK cascade
BP IEA GO:0001821 histamine secretion
Showing 1 to 6 of 40 rows rows per page

Gene expression in normal tissue: CSF2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 25BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 6

Gene-drug pathway distribution

undefined9Biosynthesis of secondary metabolites1DNA replication1Other, kinases1

Pathways in CSF2


Loading, please wait...
Database
Pathway ID
Pathway Des.
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
kegg hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
kegg hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg hsa04657 IL-17 signaling pathway - Homo sapiens (human)
kegg hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 48 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD210 AC55649 3
iGMDRD158 NSC141540 1
iGMDRD126 Tipifarnib 2
iGMDRD885 Compound 110 2
Showing 1 to 4 of 12 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSF2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.