CSF2
Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:138960 Ensembl IDEnsembl:ENSG00000164400 HGNC IDHGNC:HGNC:2434 PHARMGKB IDPA26937 Map Location5q31.1 |
GO terms in CSF2
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005576 | extracellular region |
CC | IBA | GO:0005615 | extracellular space |
CC | IDA | GO:0005615 | extracellular space |
CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
BP | TAS | GO:0000165 | MAPK cascade |
BP | IEA | GO:0001821 | histamine secretion |
Gene expression in normal tissue: CSF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSF2
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CSF2
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |