BCL10
Summary: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| B cell CLL/lymphoma 10 | MIM:603517 | Ensembl:ENSG00000142867 | HGNC:HGNC:989 | PA25299 | 1p22.3 |
GO terms in BCL10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002020 | protease binding |
| MF | IBA | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0019209 | kinase activator activity |
| MF | IDA | GO:0019209 | kinase activator activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0043422 | protein kinase B binding |
| MF | IPI | GO:0043422 | protein kinase B binding |
| MF | IPI | GO:0043621 | protein self-association |
| MF | IBA | GO:0051059 | NF-kappaB binding |
| MF | IDA | GO:0051059 | NF-kappaB binding |
| BP | IEA | GO:0001783 | B cell apoptotic process |
| BP | ISS | GO:0001843 | neural tube closure |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IC | GO:0002224 | toll-like receptor signaling pathway |
| BP | IEP | GO:0002237 | response to molecule of bacterial origin |
| BP | IBA | GO:0002250 | adaptive immune response |
| BP | IMP | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0002906 | negative regulation of mature B cell apoptotic process |
| BP | IEA | GO:0006968 | cellular defense response |
| BP | IBA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0008219 | cell death |
| BP | IEA | GO:0009620 | response to fungus |
| BP | IEA | GO:0016064 | immunoglobulin mediated immune response |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IDA | GO:0032094 | response to food |
| BP | NAS | GO:0032765 | positive regulation of mast cell cytokine production |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | NAS | GO:0042109 | lymphotoxin A biosynthetic process |
| BP | NAS | GO:0042226 | interleukin-6 biosynthetic process |
| BP | IDA | GO:0042327 | positive regulation of phosphorylation |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEP | GO:0045087 | innate immune response |
| BP | IMP | GO:0045416 | positive regulation of interleukin-8 biosynthetic process |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IEA | GO:0050856 | regulation of T cell receptor signaling pathway |
| BP | IEA | GO:0050870 | positive regulation of T cell activation |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IPI | GO:0051259 | protein complex oligomerization |
| BP | ISS | GO:0051260 | protein homooligomerization |
| BP | TAS | GO:0051260 | protein homooligomerization |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0070231 | T cell apoptotic process |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IBA | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| BP | IDA | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| CC | IEA | GO:0001772 | immunological synapse |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005764 | lysosome |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005881 | cytoplasmic microtubule |
| CC | IBA | GO:0032449 | CBM complex |
| CC | IDA | GO:0032449 | CBM complex |
| CC | NAS | GO:0032449 | CBM complex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0042101 | T cell receptor complex |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IDA | GO:0046696 | lipopolysaccharide receptor complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: BCL10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL10
CLASSFICATION
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