Summary: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

B cell CLL/lymphoma 10MIM:603517Ensembl:ENSG00000142867HGNC:HGNC:989PA252991p22.3

GO terms in BCL10

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0002020protease binding
MFIBAGO:0003713transcription coactivator activity
MFIDAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIBAGO:0019209kinase activator activity
MFIDAGO:0019209kinase activator activity
MFIPIGO:0019899enzyme binding
MFIPIGO:0019900kinase binding
MFIDAGO:0019901protein kinase binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0043422protein kinase B binding
MFIPIGO:0043422protein kinase B binding
MFIPIGO:0043621protein self-association
MFIBAGO:0051059NF-kappaB binding
MFIDAGO:0051059NF-kappaB binding
BPIEAGO:0001783B cell apoptotic process
BPISSGO:0001843neural tube closure
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPICGO:0002224toll-like receptor signaling pathway
BPIEPGO:0002237response to molecule of bacterial origin
BPIBAGO:0002250adaptive immune response
BPIMPGO:0002250adaptive immune response
BPTASGO:0002250adaptive immune response
BPIDAGO:0002906negative regulation of mature B cell apoptotic process
BPIEAGO:0006968cellular defense response
BPIBAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0008219cell death
BPIEAGO:0009620response to fungus
BPIEAGO:0016064immunoglobulin mediated immune response
BPTASGO:0016567protein ubiquitination
BPIDAGO:0031398positive regulation of protein ubiquitination
BPIDAGO:0032094response to food
BPNASGO:0032765positive regulation of mast cell cytokine production
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPNASGO:0042109lymphotoxin A biosynthetic process
BPNASGO:0042226interleukin-6 biosynthetic process
BPIDAGO:0042327positive regulation of phosphorylation
BPIBAGO:0043065positive regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEPGO:0045087innate immune response
BPIMPGO:0045416positive regulation of interleukin-8 biosynthetic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0050852T cell receptor signaling pathway
BPTASGO:0050852T cell receptor signaling pathway
BPIEAGO:0050856regulation of T cell receptor signaling pathway
BPIEAGO:0050870positive regulation of T cell activation
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIPIGO:0051259protein complex oligomerization
BPISSGO:0051260protein homooligomerization
BPTASGO:0051260protein homooligomerization
BPIEAGO:0051291protein heterooligomerization
BPIEAGO:0070231T cell apoptotic process
BPIEPGO:0071260cellular response to mechanical stimulus
BPIBAGO:2001238positive regulation of extrinsic apoptotic signaling pathway
BPIDAGO:2001238positive regulation of extrinsic apoptotic signaling pathway
CCIEAGO:0001772immunological synapse
CCIDAGO:0005881cytoplasmic microtubule
CCIBAGO:0032449CBM complex
CCIDAGO:0032449CBM complex
CCNASGO:0032449CBM complex
CCIDAGO:0032991protein-containing complex
CCIDAGO:0042101T cell receptor complex
CCIEAGO:0045121membrane raft
CCIDAGO:0046696lipopolysaccharide receptor complex
CCIDAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: BCL10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL10

DatabasePathway IDPathway Des.
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8852135Protein ubiquitination
reactomeR-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteins
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidtcr_pathwayTCR signaling in naïve CD4+ T cells

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD138PX 122
iGMDRD886Compound 1541A1
iGMDRD286Nsc 6328393

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL10