STK17A
Summary: This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
serine/threonine kinase 17a | MIM:604726 | Ensembl:ENSG00000164543 | HGNC:HGNC:11395 | PA36203 | 7p13 |
GO terms in STK17A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
MF | IBA | GO:0005524 | ATP binding |
MF | IDA | GO:0005524 | ATP binding |
BP | IDA | GO:0006468 | protein phosphorylation |
BP | IEA | GO:0006915 | apoptotic process |
BP | IDA | GO:0035556 | intracellular signal transduction |
BP | IMP | GO:0043065 | positive regulation of apoptotic process |
BP | IMP | GO:2000271 | positive regulation of fibroblast apoptotic process |
BP | IMP | GO:2000377 | regulation of reactive oxygen species metabolic process |
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005886 | plasma membrane |
CC | IDA | GO:0016607 | nuclear speck |
Gene expression in normal tissue: STK17A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK17A
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD210 | AC55649 | 1 |
iGMDRD126 | Tipifarnib | 2 |
iGMDRD318 | PAC-1 | 1 |
iGMDRD434 | BMS-536924 | 2 |
iGMDRD289 | Parthenolide | 1 |
iGMDRD105 | Triptolide | 3 |
iGMDRD577 | BIX01294 | 1 |
iGMDRD506 | Fedratinib | 1 |
iGMDRD945 | ML214 | 6 |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in STK17A