CXCL10

Summary: This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameC-X-C motif chemokine ligand 10
OMIM IDMIM:147310
Ensembl IDEnsembl:ENSG00000169245
HGNC IDHGNC:HGNC:10637
PHARMGKB IDPA35568
Map Location4q21.1

GO terms in CXCL10


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006935 chemotaxis
BP IBA GO:0006954 inflammatory response
BP IBA GO:0006955 immune response
BP TAS GO:0007165 signal transduction
BP TAS GO:0007166 cell surface receptor signaling pathway
BP IMP GO:0007186 G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: CXCL10

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

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Pathways in CXCL10


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-168256 Immune System
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-375276 Peptide ligand-binding receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD506 Fedratinib 3
iGMDRD662 JQ-1 2
iGMDRD280 CYTOCHALASIN B 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXCL10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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