CXCL10
Summary: This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-X-C motif chemokine ligand 10 | MIM:147310 | Ensembl:ENSG00000169245 | HGNC:HGNC:10637 | PA35568 | 4q21.1 |
GO terms in CXCL10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IMP | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007517 | muscle organ development |
| BP | TAS | GO:0008015 | blood circulation |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009409 | response to cold |
| BP | IEA | GO:0010332 | response to gamma radiation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IMP | GO:0010818 | T cell chemotaxis |
| BP | IDA | GO:0010819 | regulation of T cell chemotaxis |
| BP | IEA | GO:0010996 | response to auditory stimulus |
| BP | IEA | GO:0016525 | negative regulation of angiogenesis |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IBA | GO:0030595 | leukocyte chemotaxis |
| BP | IEA | GO:0033280 | response to vitamin D |
| BP | IEA | GO:0034605 | cellular response to heat |
| BP | IGI | GO:0042118 | endothelial cell activation |
| BP | IDA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0043950 | positive regulation of cAMP-mediated signaling |
| BP | IEA | GO:0045662 | negative regulation of myoblast differentiation |
| BP | IEA | GO:0045859 | regulation of protein kinase activity |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | IBA | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| BP | IBA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IMP | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IMP | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0090026 | positive regulation of monocyte chemotaxis |
| BP | IDA | GO:1901509 | regulation of endothelial tube morphogenesis |
| BP | IEA | GO:1901740 | negative regulation of myoblast fusion |
| BP | IDA | GO:2000406 | positive regulation of T cell migration |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008009 | chemokine activity |
| MF | IDA | GO:0008009 | chemokine activity |
| MF | IMP | GO:0008201 | heparin binding |
| MF | TAS | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| MF | IBA | GO:0045236 | CXCR chemokine receptor binding |
| MF | IDA | GO:0048248 | CXCR3 chemokine receptor binding |
Gene expression in normal tissue: CXCL10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXCL10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CXCL10
CLASSFICATION
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