CXCL10


Summary: This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
C-X-C motif chemokine ligand 10MIM:147310Ensembl:ENSG00000169245HGNC:HGNC:10637PA355684q21.1

GO terms in CXCL10


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006935chemotaxis
BPIBAGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPIMPGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPTASGO:0007517muscle organ development
BPTASGO:0008015blood circulation
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009409response to cold
BPIEAGO:0010332response to gamma radiation
BPIEAGO:0010469regulation of signaling receptor activity
BPIMPGO:0010818T cell chemotaxis
BPIDAGO:0010819regulation of T cell chemotaxis
BPIEAGO:0010996response to auditory stimulus
BPIEAGO:0016525negative regulation of angiogenesis
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0030593neutrophil chemotaxis
BPIBAGO:0030595leukocyte chemotaxis
BPIEAGO:0033280response to vitamin D
BPIEAGO:0034605cellular response to heat
BPIGIGO:0042118endothelial cell activation
BPIDAGO:0042127regulation of cell proliferation
BPIDAGO:0043950positive regulation of cAMP-mediated signaling
BPIEAGO:0045662negative regulation of myoblast differentiation
BPIEAGO:0045859regulation of protein kinase activity
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0051281positive regulation of release of sequestered calcium ion into cytosol
BPIEAGO:0051607defense response to virus
BPIBAGO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide
BPIBAGO:0070098chemokine-mediated signaling pathway
BPIMPGO:0070098chemokine-mediated signaling pathway
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIMPGO:0071222cellular response to lipopolysaccharide
BPIDAGO:0090026positive regulation of monocyte chemotaxis
BPIDAGO:1901509regulation of endothelial tube morphogenesis
BPIEAGO:1901740negative regulation of myoblast fusion
BPIDAGO:2000406positive regulation of T cell migration
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0009897external side of plasma membrane
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008009chemokine activity
MFIDAGO:0008009chemokine activity
MFIMPGO:0008201heparin binding
MFTASGO:0008603cAMP-dependent protein kinase regulator activity
MFIBAGO:0045236CXCR chemokine receptor binding
MFIDAGO:0048248CXCR3 chemokine receptor binding

Gene expression in normal tissue: CXCL10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXCL10


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-380108Chemokine receptors bind chemokines
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6783783Interleukin-10 signaling
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
pidcxcr3pathwayCXCR3-mediated signaling events
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP619Type II interferon signaling (IFNG)
wikipathwaysWP75Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD506Fedratinib3
iGMDRD662JQ-12
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXCL10

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