TESK1


Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
testis associated actin remodelling kinase 1MIM:601782Ensembl:ENSG00000107140HGNC:HGNC:11731PA364489p13.3

GO terms in TESK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008022protein C-terminus binding
MFIEAGO:0019901protein kinase binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0007283spermatogenesis
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0031953negative regulation of protein autophosphorylation
BPISSGO:0032880regulation of protein localization
BPISSGO:0051496positive regulation of stress fiber assembly
BPTASGO:0051496positive regulation of stress fiber assembly
BPISSGO:0071901negative regulation of protein serine/threonine kinase activity
CCTASGO:0005829cytosol
CCISSGO:0031410cytoplasmic vesicle

Gene expression in normal tissue: TESK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TESK1


DatabasePathway IDPathway Des.
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-446353Cell-extracellular matrix interactions
reactomeR-HSA-446388Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
reactomeR-HSA-446728Cell junction organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD60Quinoclamine3
iGMDRD375GW-4058335
iGMDRD353PD03259011
iGMDRD23Gossypol1
iGMDRD154NSC237663
iGMDRD887Compound 23 citrate3
iGMDRD506Fedratinib1
iGMDRD662JQ-13
iGMDRD219Bax channel blocker3
iGMDRD494Neopeltolide3
iGMDRD267Oligomycin A2
iGMDRD52Rotenone3
iGMDRD554CHEMBL14341373
iGMDRD271Brefeldin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TESK1

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