TESK1
Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| testis associated actin remodelling kinase 1 | MIM:601782 | Ensembl:ENSG00000107140 | HGNC:HGNC:11731 | PA36448 | 9p13.3 |
GO terms in TESK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0031953 | negative regulation of protein autophosphorylation |
| BP | ISS | GO:0032880 | regulation of protein localization |
| BP | ISS | GO:0051496 | positive regulation of stress fiber assembly |
| BP | TAS | GO:0051496 | positive regulation of stress fiber assembly |
| BP | ISS | GO:0071901 | negative regulation of protein serine/threonine kinase activity |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0031410 | cytoplasmic vesicle |
Gene expression in normal tissue: TESK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TESK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-446353 | Cell-extracellular matrix interactions |
| reactome | R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| reactome | R-HSA-446728 | Cell junction organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD375 | GW-405833 | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TESK1
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