STAT1
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600555 Ensembl IDEnsembl:ENSG00000115415 HGNC IDHGNC:HGNC:11362 PHARMGKB IDPA36183 Map Location2q32.2 | |||||
GO terms in STAT1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | ISS | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | IGI | GO:0002230 | positive regulation of defense response to virus by host |
| BP | IMP | GO:0002230 | positive regulation of defense response to virus by host |
| BP | ISS | GO:0003340 | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
Gene expression in normal tissue: STAT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAT1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | ifnapathway | ifn alpha signaling pathway |
| biocarta | ifngpathway | ifn gamma signaling pathway |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAT1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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