PTK6


Summary: The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602004
PHARMGKB IDPA33960
Map Location20q13.33

GO terms in PTK6


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0001726 ruffle
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
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Gene expression in normal tissue: PTK6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTK6


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Database
Pathway ID
Pathway Des.
wikipathways WP306 Focal Adhesion
wikipathways WP3826 Signaling by PTK6
wikipathways WP437 EGF-EGFR Signaling Pathway
netpath Pathway_EGFR1 EGFR1
reactome R-HSA-1227986 Signaling by ERBB2
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD85 Ursolic acid 3
iGMDRD887 Compound 23 citrate 3
iGMDRD506 Fedratinib 1
iGMDRD105 Triptolide 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTK6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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