PTK6
Summary: The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine kinase 6 | MIM:602004 | Ensembl:ENSG00000101213 | HGNC:HGNC:9617 | PA33960 | 20q13.33 |
GO terms in PTK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001726 | ruffle |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IDA | GO:0007260 | tyrosine phosphorylation of STAT protein |
| BP | TAS | GO:0009968 | negative regulation of signal transduction |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0016477 | cell migration |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | TAS | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IBA | GO:0045087 | innate immune response |
| BP | TAS | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0045926 | negative regulation of growth |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0060575 | intestinal epithelial cell differentiation |
| BP | IEA | GO:0060575 | intestinal epithelial cell differentiation |
| BP | IDA | GO:0061099 | negative regulation of protein tyrosine kinase activity |
| BP | IMP | GO:0071300 | cellular response to retinoic acid |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: PTK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3826 | Signaling by PTK6 |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-8847993 | ERBB2 Activates PTK6 Signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing |
| reactome | R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 |
| reactome | R-HSA-8849470 | PTK6 Regulates Cell Cycle |
| reactome | R-HSA-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| reactome | R-HSA-8849472 | PTK6 Down-Regulation |
| reactome | R-HSA-8849473 | PTK6 Expression |
| reactome | R-HSA-8849474 | PTK6 Activates STAT3 |
| reactome | R-HSA-8857538 | PTK6 promotes HIF1A stabilization |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD231 | Importazole | 5 |
| iGMDRD227 | Fatostatin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTK6
CLASSFICATION
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