CPB1
Summary: Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carboxypeptidase B1 | MIM:114852 | Ensembl:ENSG00000153002 | HGNC:HGNC:2299 | PA26821 | 3q24 |
GO terms in CPB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005615 | extracellular space |
| BP | IBA | GO:0006508 | proteolysis |
| BP | IEA | GO:0006508 | proteolysis |
| MF | TAS | GO:0004180 | carboxypeptidase activity |
| MF | IBA | GO:0004181 | metallocarboxypeptidase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: CPB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| reactome | R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPB1
CLASSFICATION
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